BAIT
RAB2A
LHX, RAB2
RAB2A, member RAS oncogene family
GO Process (6)
GO Function (4)
GO Component (5)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
PREY
RAB11A
YL8
RAB11A, member RAS oncogene family
GO Process (24)
GO Function (7)
GO Component (12)
Gene Ontology Biological Process
- GTP catabolic process [IBA, IDA]
- Rab protein signal transduction [IBA]
- astral microtubule organization [IMP]
- cytokinesis [IMP]
- establishment of protein localization to membrane [IMP]
- establishment of protein localization to organelle [IMP]
- establishment of vesicle localization [IMP]
- exocytosis [IBA]
- exosomal secretion [IMP]
- intracellular protein transport [IBA]
- melanosome transport [IBA, ISS]
- mitotic metaphase plate congression [IMP]
- multivesicular body assembly [IMP]
- neuron projection development [IMP]
- plasma membrane to endosome transport [NAS]
- positive regulation of G2/M transition of mitotic cell cycle [IMP]
- positive regulation of epithelial cell migration [IMP]
- protein localization to plasma membrane [IDA]
- regulation of multivesicular body size [IMP]
- regulation of vesicle-mediated transport [IMP]
- spindle assembly involved in mitosis [IMP]
- transmembrane transport [TAS]
- vesicle-mediated transport [IDA]
- water transport [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
- cleavage furrow [IDA]
- cytoplasmic vesicle [IDA]
- cytoplasmic vesicle membrane [TAS]
- extracellular vesicular exosome [IDA]
- kinetochore microtubule [IDA]
- multivesicular body [IDA]
- phagocytic vesicle [IDA]
- protein complex [IDA]
- recycling endosome [IBA, IDA, ISS]
- spindle pole [IDA]
- trans-Golgi network [IDA]
- vesicle [IDA]
Homo sapiens
Co-fractionation
Interaction inferred from the presence of two or more protein subunits in a partially purified protein preparation. If co-fractionation is demonstrated between 3 or more proteins, then add them as a complex.
Publication
Panorama of ancient metazoan macromolecular complexes
Macromolecular complexes are essential to conserved biological processes, but their prevalence across animals is unclear. By combining extensive biochemical fractionation with quantitative mass spectrometry, here we directly examined the composition of soluble multiprotein complexes among diverse metazoan models. Using an integrative approach, we generated a draft conservation map consisting of more than one million putative high-confidence co-complex interactions for species ... [more]
Nature Sep. 17, 2015; 525(7569);339-44 [Pubmed: 26344197]
Quantitative Score
- 0.096323785 [Confidence Score]
Throughput
- High Throughput
Additional Notes
- Fractionation was combined with mass spectrometry from five diverse animal species to predict co-complex protein interactions conserved across metazoa using an integrative computational scoring procedure along with an SVM approach. The significant data set of 16655 PPI, was derived from a set of more than 1M interactions by examining a ROC curve of predicted interactions against reference annotated complexes at a 67.5% cumulative precision.
Curated By
- BioGRID