BAIT
MYH1
HEL71, MYHSA1, MYHa, MyHC-2X/D, MyHC-2x
myosin, heavy chain 1, skeletal muscle, adult
GO Process (0)
GO Function (0)
GO Component (2)
Gene Ontology Cellular Component
Homo sapiens
PREY
RIMS1
CORD7, RAB3IP2, RIM, RIM1, RP5-1046G13.1
regulating synaptic membrane exocytosis 1
GO Process (14)
GO Function (4)
GO Component (3)
Gene Ontology Biological Process
- calcium ion-dependent exocytosis [TAS]
- glutamate secretion [TAS]
- membrane fusion [NAS]
- neurotransmitter secretion [TAS]
- positive regulation of excitatory postsynaptic membrane potential [ISS]
- positive regulation of gene expression [ISS]
- positive regulation of inhibitory postsynaptic membrane potential [ISS]
- protein complex assembly [IDA]
- regulated secretory pathway [NAS]
- regulation of catalytic activity [TAS]
- regulation of neurotransmitter secretion [TAS]
- secretion [NAS]
- synaptic transmission [TAS]
- synaptic vesicle exocytosis [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
Co-fractionation
Interaction inferred from the presence of two or more protein subunits in a partially purified protein preparation. If co-fractionation is demonstrated between 3 or more proteins, then add them as a complex.
Publication
Panorama of ancient metazoan macromolecular complexes
Macromolecular complexes are essential to conserved biological processes, but their prevalence across animals is unclear. By combining extensive biochemical fractionation with quantitative mass spectrometry, here we directly examined the composition of soluble multiprotein complexes among diverse metazoan models. Using an integrative approach, we generated a draft conservation map consisting of more than one million putative high-confidence co-complex interactions for species ... [more]
Nature Sep. 17, 2015; 525(7569);339-44 [Pubmed: 26344197]
Quantitative Score
- 0.073697081 [Confidence Score]
Throughput
- High Throughput
Additional Notes
- Fractionation was combined with mass spectrometry from five diverse animal species to predict co-complex protein interactions conserved across metazoa using an integrative computational scoring procedure along with an SVM approach. The significant data set of 16655 PPI, was derived from a set of more than 1M interactions by examining a ROC curve of predicted interactions against reference annotated complexes at a 67.5% cumulative precision.
Curated By
- BioGRID