BAIT
PFN2
D3S1319E, PFL
profilin 2
GO Process (8)
GO Function (4)
GO Component (1)
Gene Ontology Biological Process
- negative regulation of actin filament polymerization [IDA]
- negative regulation of epithelial cell migration [IMP]
- negative regulation of ruffle assembly [IMP]
- positive regulation of ATPase activity [IDA]
- positive regulation of actin filament bundle assembly [IMP]
- positive regulation of actin filament polymerization [IGI]
- positive regulation of peptidyl-serine phosphorylation [IMP]
- positive regulation of stress fiber assembly [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
PREY
FHOD1
FHOS
formin homology 2 domain containing 1
GO Process (2)
GO Function (2)
GO Component (4)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Homo sapiens
Two-hybrid
Bait protein expressed as a DNA binding domain (DBD) fusion and prey expressed as a transcriptional activation domain (TAD) fusion and interaction measured by reporter gene activation.
Publication
The Formin family protein, formin homolog overexpressed in spleen, interacts with the insulin-responsive aminopeptidase and profilin IIa.
Insulin stimulates translocation of glucose transporter isoform type 4 (GLUT4) and the insulin-responsive aminopeptidase (IRAP) from an intracellular storage pool to the plasma membrane in muscle and fat cells. A role for the cytoskeleton in insulin action has been postulated, and the insulin signaling pathway has been well investigated; however, the molecular mechanism by which GLUT4/IRAP-containing vesicles move from an ... [more]
Mol. Endocrinol. Jul. 01, 2003; 17(7);1216-29 [Pubmed: 12677009]
Throughput
- Low Throughput
Curated By
- BioGRID