BAIT
DUT
dUTPase
deoxyuridine triphosphatase
GO Process (8)
GO Function (4)
GO Component (4)
Gene Ontology Biological Process
- DNA replication [TAS]
- dUMP biosynthetic process [IBA]
- dUTP catabolic process [IBA]
- nucleobase-containing compound metabolic process [TAS]
- nucleobase-containing small molecule metabolic process [TAS]
- pyrimidine nucleobase metabolic process [TAS]
- pyrimidine nucleoside biosynthetic process [TAS]
- small molecule metabolic process [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
PREY
TYMS
HST422, TMS, TS, OK/SW-cl.29
thymidylate synthetase
GO Process (10)
GO Function (1)
GO Component (7)
Gene Ontology Biological Process
- G1/S transition of mitotic cell cycle [TAS]
- deoxyribonucleoside monophosphate biosynthetic process [TAS]
- mitotic cell cycle [TAS]
- nucleobase-containing compound metabolic process [TAS]
- nucleobase-containing small molecule metabolic process [TAS]
- pyrimidine nucleobase metabolic process [TAS]
- pyrimidine nucleoside biosynthetic process [TAS]
- regulation of transcription involved in G1/S transition of mitotic cell cycle [TAS]
- response to organophosphorus [IEP]
- small molecule metabolic process [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
Co-fractionation
Interaction inferred from the presence of two or more protein subunits in a partially purified protein preparation. If co-fractionation is demonstrated between 3 or more proteins, then add them as a complex.
Publication
Panorama of ancient metazoan macromolecular complexes
Macromolecular complexes are essential to conserved biological processes, but their prevalence across animals is unclear. By combining extensive biochemical fractionation with quantitative mass spectrometry, here we directly examined the composition of soluble multiprotein complexes among diverse metazoan models. Using an integrative approach, we generated a draft conservation map consisting of more than one million putative high-confidence co-complex interactions for species ... [more]
Nature Sep. 17, 2015; 525(7569);339-44 [Pubmed: 26344197]
Quantitative Score
- 0.387412379 [Confidence Score]
Throughput
- High Throughput
Additional Notes
- Fractionation was combined with mass spectrometry from five diverse animal species to predict co-complex protein interactions conserved across metazoa using an integrative computational scoring procedure along with an SVM approach. The significant data set of 16655 PPI, was derived from a set of more than 1M interactions by examining a ROC curve of predicted interactions against reference annotated complexes at a 67.5% cumulative precision.
Curated By
- BioGRID