BAIT
GCK
FGQTL3, GK, GLK, HHF3, HK4, HKIV, HXKP, LGLK, MODY2
glucokinase (hexokinase 4)
GO Process (17)
GO Function (6)
GO Component (2)
Gene Ontology Biological Process
- carbohydrate metabolic process [TAS]
- cellular glucose homeostasis [IBA]
- cellular response to insulin stimulus [ISS]
- cellular response to leptin stimulus [ISS]
- detection of glucose [IMP]
- endocrine pancreas development [TAS]
- glucose homeostasis [IMP]
- glucose transport [TAS]
- hexose transport [TAS]
- negative regulation of gluconeogenesis [IMP]
- positive regulation of glycogen biosynthetic process [IMP]
- positive regulation of insulin secretion [IMP]
- regulation of glucose transport [TAS]
- regulation of glycolytic process [NAS]
- regulation of insulin secretion [IMP]
- small molecule metabolic process [TAS]
- transmembrane transport [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
- cytosol [TAS]
- nucleoplasm [TAS]
Homo sapiens
PREY
UGP2
UDPG, UDPGP, UDPGP2, UGP1, UGPP1, UGPP2, pHC379
UDP-glucose pyrophosphorylase 2
GO Process (7)
GO Function (2)
GO Component (3)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Homo sapiens
Co-fractionation
Interaction inferred from the presence of two or more protein subunits in a partially purified protein preparation. If co-fractionation is demonstrated between 3 or more proteins, then add them as a complex.
Publication
Panorama of ancient metazoan macromolecular complexes
Macromolecular complexes are essential to conserved biological processes, but their prevalence across animals is unclear. By combining extensive biochemical fractionation with quantitative mass spectrometry, here we directly examined the composition of soluble multiprotein complexes among diverse metazoan models. Using an integrative approach, we generated a draft conservation map consisting of more than one million putative high-confidence co-complex interactions for species ... [more]
Nature Sep. 17, 2015; 525(7569);339-44 [Pubmed: 26344197]
Quantitative Score
- 0.170137042 [Confidence Score]
Throughput
- High Throughput
Additional Notes
- Fractionation was combined with mass spectrometry from five diverse animal species to predict co-complex protein interactions conserved across metazoa using an integrative computational scoring procedure along with an SVM approach. The significant data set of 16655 PPI, was derived from a set of more than 1M interactions by examining a ROC curve of predicted interactions against reference annotated complexes at a 67.5% cumulative precision.
Curated By
- BioGRID