BAIT
TRIP4
ASC-1, ASC1, HsT17391, ZC2HC5
thyroid hormone receptor interactor 4
GO Process (3)
GO Function (7)
GO Component (3)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Homo sapiens
PREY
NFKB1
EBP-1, KBF1, NF-kB1, NF-kappa-B, NF-kappaB, NFKB-p105, NFKB-p50, NFkappaB, p105, p50
nuclear factor of kappa light polypeptide gene enhancer in B-cells 1
GO Process (40)
GO Function (9)
GO Component (6)
Gene Ontology Biological Process
- Fc-epsilon receptor signaling pathway [TAS]
- MyD88-dependent toll-like receptor signaling pathway [TAS]
- MyD88-independent toll-like receptor signaling pathway [TAS]
- T cell receptor signaling pathway [TAS]
- TRIF-dependent toll-like receptor signaling pathway [TAS]
- cellular response to interleukin-1 [IEP]
- cellular response to interleukin-6 [IMP]
- cellular response to lipopolysaccharide [IMP]
- cellular response to mechanical stimulus [IEP]
- cellular response to nicotine [IMP]
- cellular response to peptide hormone stimulus [IMP]
- inflammatory response [TAS]
- innate immune response [TAS]
- membrane protein intracellular domain proteolysis [TAS]
- negative regulation of apoptotic process [TAS]
- negative regulation of calcidiol 1-monooxygenase activity [IDA]
- negative regulation of cellular protein metabolic process [IC]
- negative regulation of cholesterol transport [IC]
- negative regulation of transcription from RNA polymerase II promoter [IC, IGI, IMP]
- negative regulation of vitamin D biosynthetic process [IC]
- neurotrophin TRK receptor signaling pathway [TAS]
- positive regulation of NF-kappaB transcription factor activity [TAS]
- positive regulation of canonical Wnt signaling pathway [IMP]
- positive regulation of hyaluronan biosynthetic process [IDA]
- positive regulation of lipid storage [IC]
- positive regulation of macrophage derived foam cell differentiation [IC]
- positive regulation of miRNA metabolic process [IMP]
- positive regulation of transcription from RNA polymerase II promoter [IDA]
- positive regulation of transcription, DNA-templated [IDA, IMP, NAS]
- positive regulation of type I interferon production [TAS]
- toll-like receptor 10 signaling pathway [TAS]
- toll-like receptor 2 signaling pathway [TAS]
- toll-like receptor 3 signaling pathway [TAS]
- toll-like receptor 4 signaling pathway [TAS]
- toll-like receptor 5 signaling pathway [TAS]
- toll-like receptor 9 signaling pathway [TAS]
- toll-like receptor TLR1:TLR2 signaling pathway [TAS]
- toll-like receptor TLR6:TLR2 signaling pathway [TAS]
- toll-like receptor signaling pathway [TAS]
- transcription from RNA polymerase II promoter [TAS]
Gene Ontology Molecular Function- RNA polymerase II distal enhancer sequence-specific DNA binding [IDA]
- RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription [IDA]
- RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription [IDA]
- protein binding [IPI]
- regulatory region DNA binding [IDA]
- sequence-specific DNA binding transcription factor activity [IDA]
- transcription factor binding [IDA]
- transcription regulatory region DNA binding [IDA]
- transcription regulatory region sequence-specific DNA binding [IDA]
- RNA polymerase II distal enhancer sequence-specific DNA binding [IDA]
- RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription [IDA]
- RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription [IDA]
- protein binding [IPI]
- regulatory region DNA binding [IDA]
- sequence-specific DNA binding transcription factor activity [IDA]
- transcription factor binding [IDA]
- transcription regulatory region DNA binding [IDA]
- transcription regulatory region sequence-specific DNA binding [IDA]
Gene Ontology Cellular Component
Homo sapiens
Reconstituted Complex
An interaction is detected between purified proteins in vitro.
Publication
Novel transcription coactivator complex containing activating signal cointegrator 1.
Human activating signal cointegrator 1 (hASC-1) was originally isolated as a transcriptional coactivator of nuclear receptors. Here we report that ASC-1 exists as a steady-state complex associated with three polypeptides, P200, P100, and P50, in HeLa nuclei; stimulates transactivation by serum response factor (SRF), activating protein 1 (AP-1), and nuclear factor kappaB (NF-kappaB) through direct binding to SRF, c-Jun, p50, ... [more]
Mol. Cell. Biol. Jul. 01, 2002; 22(14);5203-11 [Pubmed: 12077347]
Throughput
- Low Throughput
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| NFKB1 TRIP4 | Reconstituted Complex Reconstituted Complex An interaction is detected between purified proteins in vitro. | Low | - | BioGRID | - | |
| NFKB1 TRIP4 | Two-hybrid Two-hybrid Bait protein expressed as a DNA binding domain (DBD) fusion and prey expressed as a transcriptional activation domain (TAD) fusion and interaction measured by reporter gene activation. | Low | - | BioGRID | - |
Curated By
- BioGRID