BAIT
ATR
FCTCS, FRP1, MEC1, SCKL, SCKL1
ATR serine/threonine kinase
GO Process (14)
GO Function (6)
GO Component (4)
Gene Ontology Biological Process
- DNA damage checkpoint [IDA]
- DNA repair [TAS]
- DNA replication [TAS]
- cell cycle [TAS]
- cellular response to DNA damage stimulus [TAS]
- cellular response to UV [IMP]
- cellular response to gamma radiation [IDA]
- double-strand break repair via homologous recombination [IBA]
- multicellular organismal development [TAS]
- negative regulation of DNA replication [IMP]
- peptidyl-serine phosphorylation [IDA]
- positive regulation of DNA damage response, signal transduction by p53 class mediator [IMP]
- protein autophosphorylation [IDA]
- replicative senescence [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
PREY
PPP2R3A
PPP2R3, PR130, PR72
protein phosphatase 2, regulatory subunit B'', alpha
GO Process (10)
GO Function (2)
GO Component (1)
Gene Ontology Biological Process
- Wnt signaling pathway involved in somitogenesis [IC]
- eye photoreceptor cell differentiation [IGI]
- negative regulation of canonical Wnt signaling pathway [IGI]
- positive regulation of canonical Wnt signaling pathway [IDA]
- positive regulation of protein catabolic process [IMP]
- protein dephosphorylation [ISS]
- regulation of catalytic activity [TAS]
- regulation of cell motility involved in somitogenic axis elongation [IGI]
- somatic muscle development [IGI]
- somite development [ISS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
Protein-peptide
An interaction is detected between a protein and a peptide derived from an interaction partner. This includes phage display experiments.
Publication
Substrate specificities and identification of putative substrates of ATM kinase family members.
Ataxia telangiectasia mutated (ATM) phosphorylates p53 protein in response to ionizing radiation, but the complex phenotype of AT cells suggests that it must have other cellular substrates as well. To identify substrates for ATM and the related kinases ATR and DNA-PK, we optimized in vitro kinase assays and developed a rapid peptide screening method to determine general phosphorylation consensus sequences. ... [more]
J. Biol. Chem. Dec. 31, 1999; 274(53);37538-43 [Pubmed: 10608806]
Throughput
- Low Throughput
Additional Notes
- in vitro kinase assay using GST-peptide substrates
Curated By
- BioGRID