BAIT
NTRK1
MTC, TRK, TRK1, TRKA, Trk-A, p140-TrkA
neurotrophic tyrosine kinase, receptor, type 1
GO Process (24)
GO Function (6)
GO Component (7)
Gene Ontology Biological Process
- Ras protein signal transduction [TAS]
- activation of MAPKK activity [TAS]
- activation of adenylate cyclase activity [TAS]
- activation of phospholipase C activity [TAS]
- axonogenesis involved in innervation [ISS]
- cellular response to nerve growth factor stimulus [ISS]
- developmental programmed cell death [ISS]
- negative regulation of cell proliferation [IDA]
- negative regulation of neuron apoptotic process [ISS]
- neurotrophin TRK receptor signaling pathway [IDA, TAS]
- peptidyl-tyrosine phosphorylation [IDA]
- phosphatidylinositol-mediated signaling [TAS]
- positive regulation of ERK1 and ERK2 cascade [IDA]
- positive regulation of NF-kappaB transcription factor activity [IDA]
- positive regulation of Ras GTPase activity [IDA]
- positive regulation of Ras protein signal transduction [IDA]
- positive regulation of angiogenesis [IDA]
- positive regulation of neuron projection development [IDA]
- positive regulation of programmed cell death [ISS]
- protein autophosphorylation [IDA]
- protein phosphorylation [IDA]
- small GTPase mediated signal transduction [TAS]
- sympathetic nervous system development [ISS]
- transmembrane receptor protein tyrosine kinase signaling pathway [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
PREY
UHRF1
ICBP90, Np95, RNF106, hNP95, hUHRF1, huNp95
ubiquitin-like with PHD and ring finger domains 1
GO Process (10)
GO Function (11)
GO Component (6)
Gene Ontology Biological Process
- cell proliferation [IEP]
- histone monoubiquitination [ISS]
- histone ubiquitination [IDA]
- maintenance of DNA methylation [IMP]
- negative regulation of transcription from RNA polymerase II promoter [IDA]
- positive regulation of DNA topoisomerase (ATP-hydrolyzing) activity [IC]
- positive regulation of cellular protein metabolic process [IDA]
- positive regulation of transcription from RNA polymerase II promoter [IC]
- protein autoubiquitination [IDA]
- protein ubiquitination involved in ubiquitin-dependent protein catabolic process [IDA]
Gene Ontology Molecular Function- core promoter proximal region sequence-specific DNA binding [IDA]
- hemi-methylated DNA-binding [IDA]
- histone binding [IDA]
- identical protein binding [ISS]
- methyl-CpG binding [IDA]
- methylated histone binding [IDA]
- nucleosomal histone binding [ISS]
- protein binding [IPI]
- sequence-specific DNA binding transcription factor activity [TAS]
- ubiquitin-protein transferase activity [IDA, ISS]
- zinc ion binding [IDA]
- core promoter proximal region sequence-specific DNA binding [IDA]
- hemi-methylated DNA-binding [IDA]
- histone binding [IDA]
- identical protein binding [ISS]
- methyl-CpG binding [IDA]
- methylated histone binding [IDA]
- nucleosomal histone binding [ISS]
- protein binding [IPI]
- sequence-specific DNA binding transcription factor activity [TAS]
- ubiquitin-protein transferase activity [IDA, ISS]
- zinc ion binding [IDA]
Gene Ontology Cellular Component
Homo sapiens
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
Temporal proteomics of NGF-TrkA signaling identifies an inhibitory role for the E3 ligase Cbl-b in neuroblastoma cell differentiation.
SH-SY5Y neuroblastoma cells respond to nerve growth factor (NGF)-mediated activation of the tropomyosin-related kinase A (TrkA) with neurite outgrowth, thereby providing a model to study neuronal differentiation. We performed a time-resolved analysis of NGF-TrkA signaling in neuroblastoma cells using mass spectrometry-based quantitative proteomics. The combination of interactome, phosphoproteome, and proteome data provided temporal insights into the molecular events downstream of ... [more]
Sci Signal Apr. 28, 2015; 8(374);ra40 [Pubmed: 25921289]
Throughput
- High Throughput
Curated By
- BioGRID