BAIT
NTRK1
MTC, TRK, TRK1, TRKA, Trk-A, p140-TrkA
neurotrophic tyrosine kinase, receptor, type 1
GO Process (24)
GO Function (6)
GO Component (7)
Gene Ontology Biological Process
- Ras protein signal transduction [TAS]
- activation of MAPKK activity [TAS]
- activation of adenylate cyclase activity [TAS]
- activation of phospholipase C activity [TAS]
- axonogenesis involved in innervation [ISS]
- cellular response to nerve growth factor stimulus [ISS]
- developmental programmed cell death [ISS]
- negative regulation of cell proliferation [IDA]
- negative regulation of neuron apoptotic process [ISS]
- neurotrophin TRK receptor signaling pathway [IDA, TAS]
- peptidyl-tyrosine phosphorylation [IDA]
- phosphatidylinositol-mediated signaling [TAS]
- positive regulation of ERK1 and ERK2 cascade [IDA]
- positive regulation of NF-kappaB transcription factor activity [IDA]
- positive regulation of Ras GTPase activity [IDA]
- positive regulation of Ras protein signal transduction [IDA]
- positive regulation of angiogenesis [IDA]
- positive regulation of neuron projection development [IDA]
- positive regulation of programmed cell death [ISS]
- protein autophosphorylation [IDA]
- protein phosphorylation [IDA]
- small GTPase mediated signal transduction [TAS]
- sympathetic nervous system development [ISS]
- transmembrane receptor protein tyrosine kinase signaling pathway [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
PREY
CLIC4
CLIC4L, H1, MTCLIC, huH1, p64H1
chloride intracellular channel 4
GO Process (8)
GO Function (2)
GO Component (16)
Gene Ontology Biological Process
- cell differentiation [TAS]
- cellular response to calcium ion [IMP]
- chloride transmembrane transport [TAS]
- chloride transport [NAS]
- establishment or maintenance of apical/basal cell polarity [NAS]
- keratinocyte differentiation [IMP]
- negative regulation of cell migration [IDA]
- regulation of cytoskeleton organization [NAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
- actin cytoskeleton [TAS]
- apical part of cell [IDA]
- cell surface [IDA]
- cell-cell junction [IDA]
- centrosome [IDA]
- cytoplasm [IDA]
- cytosol [IDA]
- extracellular vesicular exosome [IDA]
- intracellular [IDA]
- microtubule cytoskeleton [IDA]
- microvillus [IDA]
- midbody [IDA]
- mitochondrion [IDA]
- nuclear matrix [IDA]
- perinuclear region of cytoplasm [IDA]
- plasma membrane [IDA]
Homo sapiens
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
Temporal proteomics of NGF-TrkA signaling identifies an inhibitory role for the E3 ligase Cbl-b in neuroblastoma cell differentiation.
SH-SY5Y neuroblastoma cells respond to nerve growth factor (NGF)-mediated activation of the tropomyosin-related kinase A (TrkA) with neurite outgrowth, thereby providing a model to study neuronal differentiation. We performed a time-resolved analysis of NGF-TrkA signaling in neuroblastoma cells using mass spectrometry-based quantitative proteomics. The combination of interactome, phosphoproteome, and proteome data provided temporal insights into the molecular events downstream of ... [more]
Sci Signal Apr. 28, 2015; 8(374);ra40 [Pubmed: 25921289]
Throughput
- High Throughput
Curated By
- BioGRID