BAIT
NTRK1
MTC, TRK, TRK1, TRKA, Trk-A, p140-TrkA
neurotrophic tyrosine kinase, receptor, type 1
GO Process (24)
GO Function (6)
GO Component (7)
Gene Ontology Biological Process
- Ras protein signal transduction [TAS]
- activation of MAPKK activity [TAS]
- activation of adenylate cyclase activity [TAS]
- activation of phospholipase C activity [TAS]
- axonogenesis involved in innervation [ISS]
- cellular response to nerve growth factor stimulus [ISS]
- developmental programmed cell death [ISS]
- negative regulation of cell proliferation [IDA]
- negative regulation of neuron apoptotic process [ISS]
- neurotrophin TRK receptor signaling pathway [IDA, TAS]
- peptidyl-tyrosine phosphorylation [IDA]
- phosphatidylinositol-mediated signaling [TAS]
- positive regulation of ERK1 and ERK2 cascade [IDA]
- positive regulation of NF-kappaB transcription factor activity [IDA]
- positive regulation of Ras GTPase activity [IDA]
- positive regulation of Ras protein signal transduction [IDA]
- positive regulation of angiogenesis [IDA]
- positive regulation of neuron projection development [IDA]
- positive regulation of programmed cell death [ISS]
- protein autophosphorylation [IDA]
- protein phosphorylation [IDA]
- small GTPase mediated signal transduction [TAS]
- sympathetic nervous system development [ISS]
- transmembrane receptor protein tyrosine kinase signaling pathway [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
PREY
ANK2
ANK-2, LQT4, brank-2
ankyrin 2, neuronal
GO Process (36)
GO Function (7)
GO Component (11)
Gene Ontology Biological Process
- SA node cell action potential [ISS]
- SA node cell to atrial cardiac muscle cell communication [IMP]
- T-tubule organization [ISS]
- atrial cardiac muscle cell action potential [IMP]
- atrial cardiac muscle cell to AV node cell communication [ISS]
- atrial septum development [IMP]
- axon guidance [TAS]
- cellular calcium ion homeostasis [ISS]
- cellular protein localization [IGI]
- membrane depolarization during SA node cell action potential [TAS]
- positive regulation of calcium ion transmembrane transporter activity [ISS]
- positive regulation of calcium ion transport [ISS]
- positive regulation of cation channel activity [ISS]
- positive regulation of gene expression [IGI]
- positive regulation of potassium ion transmembrane transporter activity [ISS]
- positive regulation of potassium ion transport [ISS]
- protein localization to M-band [ISS]
- protein localization to T-tubule [ISS]
- protein localization to cell surface [ISS]
- protein localization to endoplasmic reticulum [IGI]
- protein localization to organelle [IGI]
- protein localization to plasma membrane [IGI, ISS]
- protein stabilization [ISS]
- regulation of calcium ion transmembrane transporter activity [ISS]
- regulation of calcium ion transport [IGI]
- regulation of cardiac muscle cell contraction [IGI]
- regulation of cardiac muscle contraction [IMP]
- regulation of cardiac muscle contraction by calcium ion signaling [IMP]
- regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion [IGI, ISS]
- regulation of heart rate [IMP]
- regulation of heart rate by cardiac conduction [IMP, ISS]
- regulation of protein stability [IC]
- regulation of release of sequestered calcium ion into cytosol [IGI]
- regulation of ventricular cardiac muscle cell membrane repolarization [IMP]
- sarcoplasmic reticulum calcium ion transport [TAS]
- ventricular cardiac muscle cell action potential [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
Temporal proteomics of NGF-TrkA signaling identifies an inhibitory role for the E3 ligase Cbl-b in neuroblastoma cell differentiation.
SH-SY5Y neuroblastoma cells respond to nerve growth factor (NGF)-mediated activation of the tropomyosin-related kinase A (TrkA) with neurite outgrowth, thereby providing a model to study neuronal differentiation. We performed a time-resolved analysis of NGF-TrkA signaling in neuroblastoma cells using mass spectrometry-based quantitative proteomics. The combination of interactome, phosphoproteome, and proteome data provided temporal insights into the molecular events downstream of ... [more]
Sci Signal Apr. 28, 2015; 8(374);ra40 [Pubmed: 25921289]
Throughput
- High Throughput
Curated By
- BioGRID