BAIT
MX1
IFI-78K, IFI78, MX, MxA
MX dynamin-like GTPase 1
GO Process (9)
GO Function (1)
GO Component (4)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
PREY
DAXX
BING2, DAP6, EAP1, DADB-159G18.9
death-domain associated protein
GO Process (12)
GO Function (14)
GO Component (5)
Gene Ontology Biological Process
- activation of JUN kinase activity [TAS]
- androgen receptor signaling pathway [IDA]
- apoptotic process [TAS]
- chromatin remodeling [IDA]
- extrinsic apoptotic signaling pathway via death domain receptors [TAS]
- negative regulation of transcription, DNA-templated [IDA]
- nucleosome assembly [IDA]
- positive regulation of neuron death [IGI]
- positive regulation of protein kinase activity [IGI]
- positive regulation of protein phosphorylation [IGI]
- regulation of protein ubiquitination [IDA]
- regulation of transcription, DNA-templated [IDA]
Gene Ontology Molecular Function- androgen receptor binding [IPI]
- enzyme binding [IPI]
- heat shock protein binding [TAS]
- histone binding [IDA]
- p53 binding [IPI]
- protein N-terminus binding [IPI]
- protein binding [IPI]
- protein homodimerization activity [IDA]
- protein kinase activator activity [IGI]
- protein kinase binding [IPI]
- receptor signaling protein activity [TAS]
- transcription corepressor activity [IDA]
- transcription factor binding [IDA]
- ubiquitin protein ligase binding [IPI]
- androgen receptor binding [IPI]
- enzyme binding [IPI]
- heat shock protein binding [TAS]
- histone binding [IDA]
- p53 binding [IPI]
- protein N-terminus binding [IPI]
- protein binding [IPI]
- protein homodimerization activity [IDA]
- protein kinase activator activity [IGI]
- protein kinase binding [IPI]
- receptor signaling protein activity [TAS]
- transcription corepressor activity [IDA]
- transcription factor binding [IDA]
- ubiquitin protein ligase binding [IPI]
Homo sapiens
Two-hybrid
Bait protein expressed as a DNA binding domain (DBD) fusion and prey expressed as a transcriptional activation domain (TAD) fusion and interaction measured by reporter gene activation.
Publication
MxA interacts with and is modified by the SUMOylation machinery.
Mx proteins are evolutionarily conserved dynamin-like large GTPases involved in viral resistance triggered by types I and III interferons. The human MxA is a cytoplasmic protein that confers resistance to a large number of viruses. The MxA protein is also known to self-assembly into high molecular weight homo-oligomers. Using a yeast two-hybrid screen, we identified 27 MxA binding partners, some ... [more]
Exp. Cell Res. Jan. 01, 2015; 330(1);151-63 [Pubmed: 25447205]
Throughput
- Low Throughput
Related interactions
Curated By
- BioGRID