BAIT

STH1

NPS1, RSC chromatin remodeling complex ATPase subunit STH1, L000002128, YIL126W
ATPase component of the RSC chromatin remodeling complex; required for expression of early meiotic genes; promotes base excision repair in chromatin; essential helicase-related protein homologous to Snf2p
Saccharomyces cerevisiae (S288c)
PREY

MRPL4

mitochondrial 54S ribosomal protein YmL4, YmL4, L000002523, L000001160, YLR439W
Mitochondrial ribosomal protein of the large subunit; homolog of prokaryotic L29 ribosomal protein; located at the ribosomal tunnel exit
GO Process (1)
GO Function (1)
GO Component (2)

Gene Ontology Biological Process

Gene Ontology Molecular Function

Gene Ontology Cellular Component

Saccharomyces cerevisiae (S288c)

Synthetic Growth Defect

A genetic interaction is inferred when mutations in separate genes, each of which alone causes a minimal phenotype, result in a significant growth defect under a given condition when combined in the same cell.

Publication

RSC Chromatin-Remodeling Complex Is Important for Mitochondrial Function in Saccharomyces cerevisiae.

Imamura Y, Yu F, Nakamura M, Chihara Y, Okane K, Sato M, Kanai M, Hamada R, Ueno M, Yukawa M, Tsuchiya E

RSC (Remodel the Structure of Chromatin) is an ATP-dependent chromatin remodeling complex essential for the growth of Saccharomyces cerevisiae. RSC exists as two distinct isoforms that share core subunits including the ATPase subunit Nps1/Sth1 but contain either Rsc1or Rsc2. Using the synthetic genetic array (SGA) of the non-essential null mutation method, we screened for mutations exhibiting synthetic growth defects in ... [more]

PLoS ONE Jun. 19, 2015; 10(6);e0130397 [Pubmed: 26086550]

Throughput

  • High Throughput

Ontology Terms

  • phenotype: vegetative growth (APO:0000106)

Additional Notes

  • SGA performed with nps1-105 as bait
  • Table 4

Curated By

  • BioGRID