BAIT
CBLB
AI429560, AI851073, Cbl-b
Casitas B-lineage lymphoma b
GO Process (8)
GO Function (2)
GO Component (4)
Gene Ontology Biological Process
- T cell activation [IMP]
- immune response [IMP]
- intracellular signal transduction [IMP]
- negative regulation of T cell receptor signaling pathway [IMP]
- negative regulation of alpha-beta T cell proliferation [IMP]
- positive regulation of T cell anergy [IMP]
- positive regulation of protein catabolic process [IMP]
- signal transduction [ISO]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Mus musculus
PREY
ITK
Emt, Tcsk, Tsk, RP23-273O7.1
IL2 inducible T cell kinase
GO Process (12)
GO Function (2)
GO Component (2)
Gene Ontology Biological Process
- NK T cell differentiation [IGI, IMP]
- T cell receptor signaling pathway [IMP]
- activation of phospholipase C activity [IMP]
- adaptive immune response [IMP]
- cytokine production [IMP]
- innate immune response [IBA]
- interferon-gamma production [IGI, IMP]
- interleukin-4 production [IGI, IMP]
- peptidyl-tyrosine autophosphorylation [IBA]
- peptidyl-tyrosine phosphorylation [ISO]
- regulation of cell proliferation [IBA]
- transmembrane receptor protein tyrosine kinase signaling pathway [IBA]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Mus musculus
Synthetic Rescue
A genetic interaction is inferred when mutations or deletions of one gene rescues the lethality or growth defect of a strain mutated or deleted for another gene.
Publication
Impaired T-cell development in the absence of Vav1 and Itk.
Vav1 and the Tec family kinase Itk act in similar T-cell activation pathways. Both molecules interact with members of the Cbl family of E3 ubiquitin ligases, and signaling defects in Vav1(-/-) T cells are rescued upon deletion of Cbl-b. In this study we investigate the relation between Itk and Cbl-b or Vav1 by generating Itk/Cbl-b and Itk/Vav1 double-deficient mice. Deletion ... [more]
Eur. J. Immunol. Dec. 01, 2008; 38(12);3530-42 [Pubmed: 19009524]
Throughput
- Low Throughput
Additional Notes
- figure 1.
Curated By
- BioGRID