RAS2
Gene Ontology Biological Process
- activation of adenylate cyclase activity [IDA]
- ascospore formation [IMP]
- positive regulation of adenylate cyclase activity [IGI]
- positive regulation of pseudohyphal growth [IMP]
- positive regulation of transcription by galactose [IMP]
- protein localization to bud neck [IGI]
- regulation of protein localization [IMP]
- replicative cell aging [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
SLA1
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Phenotypic Suppression
A genetic interaction is inferred when mutation or over expression of one gene results in suppression of any phenotype (other than lethality/growth defect) associated with mutation or over expression of another gene.
Publication
The longevity of tor1Δ, sch9Δ, and ras2Δ mutants depends on actin dynamics in Saccharomyces cerevisiae.
Recent studies have revealed the role of actin dynamics in the regulation of yeast aging. Although the target of rapamycin (TOR) complex, serine/threonine kinase Sch9, and Ras2 have been shown to play important roles in aging for a long time, the relationship between these regulators and actin has not yet been reported. In this study we investigated the roles of ... [more]
Throughput
- Low Throughput
Ontology Terms
- phenotype: chronological lifespan (APO:0000316)
Additional Notes
- Figure 3
- SLA1 deletion reverses increased chronological life span observed in ras2 mutant
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| RAS2 SLA1 | Negative Genetic Negative Genetic Mutations/deletions in separate genes, each of which alone causes a minimal phenotype, but when combined in the same cell results in a more severe fitness defect or lethality under a given condition. This term is reserved for high or low throughput studies with scores. | High | -0.1356 | BioGRID | 2169417 |
Curated By
- BioGRID