LNX2
Gene Ontology Molecular Function
HOXA1
Gene Ontology Biological Process
- abducens nerve formation [ISO]
- anatomical structure formation involved in morphogenesis [IGI]
- anatomical structure morphogenesis [IGI, ISO]
- anterior/posterior pattern specification [IGI, IMP]
- artery development [ISO]
- artery morphogenesis [ISO]
- cellular response to retinoic acid [IDA]
- central nervous system neuron differentiation [IMP]
- cochlea development [ISO]
- cochlea morphogenesis [ISO]
- cognition [ISO]
- embryonic neurocranium morphogenesis [ISO]
- facial nerve structural organization [IGI]
- facial nucleus development [IMP]
- hindbrain development [IMP]
- inner ear development [ISO]
- inner ear morphogenesis [IMP]
- motor neuron axon guidance [IGI]
- nervous system development [IMP]
- neuromuscular process [ISO]
- optokinetic behavior [ISO]
- outer ear morphogenesis [ISO]
- positive regulation of transcription from RNA polymerase II promoter [IDA]
- regulation of behavior [ISO]
- regulation of transcription from RNA polymerase II promoter [IDA]
- rhombomere 3 development [IGI, IMP]
- rhombomere 4 development [IGI, IMP]
- rhombomere 5 development [IGI, IMP]
- semicircular canal formation [ISO]
- sensory perception of sound [ISO]
Gene Ontology Molecular Function
Affinity Capture-Western
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.
Publication
Protein interactions of the transcription factor Hoxa1.
Hox proteins are transcription factors involved in crucial processes during animal development. Their mode of action remains scantily documented. While other families of transcription factors, like Smad or Stat, are known cell signaling transducers, such a function has never been squarely addressed for Hox proteins.To investigate the mode of action of mammalian Hoxa1, we characterized its interactome by a systematic ... [more]
Throughput
- High Throughput
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| HOXA1 LNX2 | PCA PCA A Protein-Fragment Complementation Assay (PCA) is a protein-protein interaction assay in which a bait protein is expressed as fusion to one of the either N- or C- terminal peptide fragments of a reporter protein and prey protein is expressed as fusion to the complementary N- or C- terminal fragment of the same reporter protein. Interaction of bait and prey proteins bring together complementary fragments, which can then fold into an active reporter, e.g. the split-ubiquitin assay. | High | - | BioGRID | - | |
| HOXA1 LNX2 | Two-hybrid Two-hybrid Bait protein expressed as a DNA binding domain (DBD) fusion and prey expressed as a transcriptional activation domain (TAD) fusion and interaction measured by reporter gene activation. | Low/High | - | BioGRID | - |
Curated By
- BioGRID