BAIT
AR
AIS, DHTR, HUMARA, HYSP1, KD, NR3C4, SBMA, SMAX1, TFM, RP11-383C12.1
androgen receptor
GO Process (23)
GO Function (16)
GO Component (5)
Gene Ontology Biological Process
- androgen receptor signaling pathway [IDA]
- cell growth [NAS]
- cell proliferation [NAS]
- cell-cell signaling [TAS]
- gene expression [TAS]
- intracellular receptor signaling pathway [IDA]
- negative regulation of extrinsic apoptotic signaling pathway [IDA]
- negative regulation of integrin biosynthetic process [IDA]
- positive regulation of NF-kappaB transcription factor activity [IMP]
- positive regulation of cell proliferation [IDA]
- positive regulation of integrin biosynthetic process [IDA]
- positive regulation of phosphorylation [IMP]
- positive regulation of transcription from RNA polymerase II promoter [IDA, IMP]
- positive regulation of transcription from RNA polymerase III promoter [IDA]
- positive regulation of transcription, DNA-templated [IDA]
- prostate gland development [NAS]
- protein oligomerization [IDA]
- regulation of establishment of protein localization to plasma membrane [IDA]
- sex differentiation [NAS]
- signal transduction [TAS]
- transcription initiation from RNA polymerase II promoter [TAS]
- transcription, DNA-templated [IDA]
- transport [TAS]
Gene Ontology Molecular Function- DNA binding [NAS]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding [IDA]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription [IDA]
- RNA polymerase II transcription factor binding [IPI]
- androgen binding [NAS]
- androgen receptor activity [IDA, IMP, NAS, TAS]
- beta-catenin binding [IDA, IPI, TAS]
- chromatin binding [IDA]
- enzyme binding [IPI]
- ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity [IDA]
- protein binding [IPI]
- protein dimerization activity [NAS]
- receptor binding [IPI]
- sequence-specific DNA binding transcription factor activity [IDA]
- transcription factor binding [IPI]
- transcription regulatory region DNA binding [IDA]
- DNA binding [NAS]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding [IDA]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription [IDA]
- RNA polymerase II transcription factor binding [IPI]
- androgen binding [NAS]
- androgen receptor activity [IDA, IMP, NAS, TAS]
- beta-catenin binding [IDA, IPI, TAS]
- chromatin binding [IDA]
- enzyme binding [IPI]
- ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity [IDA]
- protein binding [IPI]
- protein dimerization activity [NAS]
- receptor binding [IPI]
- sequence-specific DNA binding transcription factor activity [IDA]
- transcription factor binding [IPI]
- transcription regulatory region DNA binding [IDA]
Gene Ontology Cellular Component
Homo sapiens
PREY
TCF7L2
TCF-4, TCF4, RP11-357H24.1
transcription factor 7-like 2 (T-cell specific, HMG-box)
GO Process (28)
GO Function (13)
GO Component (7)
Gene Ontology Biological Process
- blood vessel development [IMP]
- brain development [IBA]
- canonical Wnt signaling pathway [IC]
- canonical Wnt signaling pathway involved in positive regulation of epithelial to mesenchymal transition [IMP]
- cell cycle arrest [IMP]
- cell proliferation [IMP]
- fat cell differentiation [IDA]
- generation of neurons [IBA]
- glucose homeostasis [IDA]
- maintenance of DNA repeat elements [IMP]
- myoblast fate commitment [IDA]
- negative regulation of canonical Wnt signaling pathway [IMP]
- negative regulation of extrinsic apoptotic signaling pathway [IDA]
- negative regulation of sequence-specific DNA binding transcription factor activity [IDA]
- negative regulation of transcription from RNA polymerase II promoter [IDA]
- negative regulation of transcription, DNA-templated [IDA, IMP]
- negative regulation of type B pancreatic cell apoptotic process [IDA]
- pancreas development [TAS]
- positive regulation of heparan sulfate proteoglycan biosynthetic process [IMP]
- positive regulation of insulin secretion [IDA, IMP]
- positive regulation of protein binding [IDA]
- positive regulation of protein export from nucleus [IMP]
- positive regulation of protein kinase B signaling [IMP]
- positive regulation of transcription from RNA polymerase II promoter [IDA]
- regulation of hormone metabolic process [IDA]
- regulation of smooth muscle cell proliferation [IMP]
- regulation of transcription from RNA polymerase II promoter [IDA]
- response to glucose [ISS]
Gene Ontology Molecular Function- RNA polymerase II core promoter proximal region sequence-specific DNA binding [IDA]
- RNA polymerase II repressing transcription factor binding [IPI]
- armadillo repeat domain binding [IPI]
- beta-catenin binding [IDA, IPI]
- chromatin binding [IBA]
- gamma-catenin binding [IPI]
- nuclear hormone receptor binding [IPI]
- protein binding [IPI]
- protein kinase binding [IPI]
- sequence-specific DNA binding [IDA, IMP]
- sequence-specific DNA binding transcription factor activity [IDA]
- transcription factor binding [IPI]
- transcription regulatory region DNA binding [IDA]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding [IDA]
- RNA polymerase II repressing transcription factor binding [IPI]
- armadillo repeat domain binding [IPI]
- beta-catenin binding [IDA, IPI]
- chromatin binding [IBA]
- gamma-catenin binding [IPI]
- nuclear hormone receptor binding [IPI]
- protein binding [IPI]
- protein kinase binding [IPI]
- sequence-specific DNA binding [IDA, IMP]
- sequence-specific DNA binding transcription factor activity [IDA]
- transcription factor binding [IPI]
- transcription regulatory region DNA binding [IDA]
Gene Ontology Cellular Component
Homo sapiens
Reconstituted Complex
An interaction is detected between purified proteins in vitro.
Publication
A direct beta-catenin-independent interaction between androgen receptor and T cell factor 4.
T cell factor (Tcf) proteins bind beta-catenin and are downstream effectors of Wnt/beta-catenin signals. A recently demonstrated interaction between beta-catenin and the androgen receptor (AR) ligand binding domain has suggested that AR may be a Tcf-independent Wnt/beta-catenin effector. This study demonstrates that there is a direct interaction between the AR DNA binding domain (DBD) and Tcf4. Tcf4 bound specifically to ... [more]
J. Biol. Chem. Aug. 15, 2003; 278(33);30828-34 [Pubmed: 12799378]
Throughput
- Low Throughput
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| AR TCF7L2 | Affinity Capture-Western Affinity Capture-Western An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins. | Low | - | BioGRID | - |
Curated By
- BioGRID