TCF7L2
Gene Ontology Biological Process
- blood vessel development [IMP]
- brain development [IBA]
- canonical Wnt signaling pathway [IC]
- canonical Wnt signaling pathway involved in positive regulation of epithelial to mesenchymal transition [IMP]
- cell cycle arrest [IMP]
- cell proliferation [IMP]
- fat cell differentiation [IDA]
- generation of neurons [IBA]
- glucose homeostasis [IDA]
- maintenance of DNA repeat elements [IMP]
- myoblast fate commitment [IDA]
- negative regulation of canonical Wnt signaling pathway [IMP]
- negative regulation of extrinsic apoptotic signaling pathway [IDA]
- negative regulation of sequence-specific DNA binding transcription factor activity [IDA]
- negative regulation of transcription from RNA polymerase II promoter [IDA]
- negative regulation of transcription, DNA-templated [IDA, IMP]
- negative regulation of type B pancreatic cell apoptotic process [IDA]
- pancreas development [TAS]
- positive regulation of heparan sulfate proteoglycan biosynthetic process [IMP]
- positive regulation of insulin secretion [IDA, IMP]
- positive regulation of protein binding [IDA]
- positive regulation of protein export from nucleus [IMP]
- positive regulation of protein kinase B signaling [IMP]
- positive regulation of transcription from RNA polymerase II promoter [IDA]
- regulation of hormone metabolic process [IDA]
- regulation of smooth muscle cell proliferation [IMP]
- regulation of transcription from RNA polymerase II promoter [IDA]
- response to glucose [ISS]
Gene Ontology Molecular Function- RNA polymerase II core promoter proximal region sequence-specific DNA binding [IDA]
- RNA polymerase II repressing transcription factor binding [IPI]
- armadillo repeat domain binding [IPI]
- beta-catenin binding [IDA, IPI]
- chromatin binding [IBA]
- gamma-catenin binding [IPI]
- nuclear hormone receptor binding [IPI]
- protein binding [IPI]
- protein kinase binding [IPI]
- sequence-specific DNA binding [IDA, IMP]
- sequence-specific DNA binding transcription factor activity [IDA]
- transcription factor binding [IPI]
- transcription regulatory region DNA binding [IDA]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding [IDA]
- RNA polymerase II repressing transcription factor binding [IPI]
- armadillo repeat domain binding [IPI]
- beta-catenin binding [IDA, IPI]
- chromatin binding [IBA]
- gamma-catenin binding [IPI]
- nuclear hormone receptor binding [IPI]
- protein binding [IPI]
- protein kinase binding [IPI]
- sequence-specific DNA binding [IDA, IMP]
- sequence-specific DNA binding transcription factor activity [IDA]
- transcription factor binding [IPI]
- transcription regulatory region DNA binding [IDA]
Gene Ontology Cellular Component
Affinity Capture-Western
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.
Publication
Beta-catenin interacts with the FUS proto-oncogene product and regulates pre-mRNA splicing.
beta-Catenin is a downstream effector of the Wnt signaling pathway and is believed to exert its oncogenic function by activating T-cell factor (TCF)/lymphoid enhancer factor (LEF) family transcriptional factors. However, it is still uncertain whether the diverse effects of beta-catenin are caused solely by aberrant gene transactivation. In this study, we used a proteomics approach to obtain further insight into ... [more]
Throughput
- Low Throughput
Curated By
- BioGRID