GRIP1
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
AR
Gene Ontology Biological Process
- Leydig cell differentiation [IMP]
- activation of prostate induction by androgen receptor signaling pathway [IMP]
- androgen receptor signaling pathway [IDA, ISO]
- cellular process [IDA]
- epithelial cell differentiation involved in prostate gland development [IMP]
- epithelial cell morphogenesis [IGI]
- fertilization [IMP]
- in utero embryonic development [IMP]
- intracellular receptor signaling pathway [ISO]
- lateral sprouting involved in mammary gland duct morphogenesis [IMP]
- male genitalia morphogenesis [IMP]
- male gonad development [IGI, IMP]
- male sex differentiation [ISO]
- male somatic sex determination [IMP]
- mammary gland alveolus development [IMP]
- morphogenesis of an epithelial fold [IMP]
- multicellular organism growth [IGI]
- negative regulation of epithelial cell proliferation [IMP]
- negative regulation of extrinsic apoptotic signaling pathway [ISO]
- negative regulation of integrin biosynthetic process [ISO]
- organ formation [IMP]
- positive regulation of MAPK cascade [IMP]
- positive regulation of NF-kappaB transcription factor activity [ISO]
- positive regulation of cell proliferation [ISO]
- positive regulation of insulin-like growth factor receptor signaling pathway [IMP]
- positive regulation of integrin biosynthetic process [ISO]
- positive regulation of intracellular estrogen receptor signaling pathway [IMP]
- positive regulation of phosphorylation [ISO]
- positive regulation of transcription from RNA polymerase II promoter [IDA, IGI, IMP, ISO]
- positive regulation of transcription from RNA polymerase III promoter [ISO]
- positive regulation of transcription, DNA-templated [ISO]
- prostate gland epithelium morphogenesis [IMP]
- prostate gland growth [IMP]
- protein oligomerization [ISO]
- regulation of catalytic activity [IMP]
- regulation of developmental growth [IMP]
- regulation of establishment of protein localization to plasma membrane [ISO]
- regulation of gene expression [IMP]
- regulation of prostatic bud formation [IGI]
- regulation of systemic arterial blood pressure [IGI]
- regulation of transcription from RNA polymerase II promoter [IMP]
- regulation of transcription, DNA-templated [IDA]
- reproductive structure development [IMP]
- reproductive system development [IGI]
- seminiferous tubule development [IGI, IMP]
- single fertilization [IGI]
- spermatogenesis [IMP]
- steroid hormone mediated signaling pathway [ISO]
- tertiary branching involved in mammary gland duct morphogenesis [IMP]
- transcription from RNA polymerase II promoter [ISO]
- transcription, DNA-templated [ISO]
Gene Ontology Molecular Function- POU domain binding [IDA]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding [ISO]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription [ISO]
- RNA polymerase II transcription factor binding [ISO]
- androgen binding [ISO]
- androgen receptor activity [IDA, ISO]
- androgen receptor binding [ISO]
- beta-catenin binding [ISO]
- chromatin binding [ISO]
- enzyme binding [IPI, ISO]
- ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity [ISO]
- protein binding [IPI]
- protein domain specific binding [ISO]
- receptor binding [ISO]
- sequence-specific DNA binding [IDA]
- sequence-specific DNA binding transcription factor activity [IDA, ISO]
- transcription factor binding [ISO]
- transcription regulatory region DNA binding [ISO]
- POU domain binding [IDA]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding [ISO]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription [ISO]
- RNA polymerase II transcription factor binding [ISO]
- androgen binding [ISO]
- androgen receptor activity [IDA, ISO]
- androgen receptor binding [ISO]
- beta-catenin binding [ISO]
- chromatin binding [ISO]
- enzyme binding [IPI, ISO]
- ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity [ISO]
- protein binding [IPI]
- protein domain specific binding [ISO]
- receptor binding [ISO]
- sequence-specific DNA binding [IDA]
- sequence-specific DNA binding transcription factor activity [IDA, ISO]
- transcription factor binding [ISO]
- transcription regulatory region DNA binding [ISO]
Two-hybrid
Bait protein expressed as a DNA binding domain (DBD) fusion and prey expressed as a transcriptional activation domain (TAD) fusion and interaction measured by reporter gene activation.
Publication
GRIP1, a novel mouse protein that serves as a transcriptional coactivator in yeast for the hormone binding domains of steroid receptors.
The yeast two-hybrid system was used to isolate a clone from a 17-day-old mouse embryo cDNA library that codes for a novel 812-aa long protein fragment, glucocorticoid receptor-interacting protein 1 (GRIP1), that can interact with the hormone binding domain (HBD) of the glucocorticoid receptor. In the yeast two-hybrid system and in vitro, GRIP1 interacted with the HBDs of the glucocorticoid, ... [more]
Throughput
- Low Throughput
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| GRIP1 AR | Affinity Capture-Western Affinity Capture-Western An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins. | Low | - | BioGRID | - |
Curated By
- BioGRID