AKAP13
Gene Ontology Biological Process
Gene Ontology Molecular Function
PRKCH
Gene Ontology Biological Process
- negative regulation of glial cell apoptotic process [ISO, ISS]
- positive regulation of B cell receptor signaling pathway [ISO, ISS]
- positive regulation of NF-kappaB transcription factor activity [ISO, ISS]
- positive regulation of glial cell proliferation [ISO, ISS]
- positive regulation of keratinocyte differentiation [ISO, ISS]
- positive regulation of macrophage derived foam cell differentiation [ISO, ISS]
- protein kinase C signaling [IMP]
- protein phosphorylation [IDA, ISO]
- regulation of tight junction assembly [ISO, ISS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Reconstituted Complex
An interaction is inferred between proteins in vitro. This can include proteins in recombinant form or proteins isolated directly from cells with recombinant or purified bait. For example, GST pull-down assays where a GST-tagged protein is first isolated and then used to fish interactors from cell lysates are considered reconstituted complexes (e.g. PUBMED: 14657240, Fig. 4A or PUBMED: 14761940, Fig. 5). This can also include gel-shifts, surface plasmon resonance, isothermal titration calorimetry (ITC) and bio-layer interferometry (BLI) experiments. The bait-hit directionality may not be clear for 2 interacting proteins. In these cases the directionality is up to the discretion of the curator.
Publication
AKAP-Lbc nucleates a protein kinase D activation scaffold.
The transmission of cellular signals often proceeds through multiprotein complexes where enzymes are positioned in proximity to their upstream activators and downstream substrates. In this report we demonstrate that the A-kinase anchoring protein AKAP-Lbc assembles an activation complex for the lipid-dependent enzyme protein kinase D (PKD). Using a combination of biochemical, enzymatic, and immunofluorescence techniques, we show that the anchoring ... [more]
Throughput
- Low Throughput
Curated By
- BioGRID