LEP
Gene Ontology Biological Process
- adipose tissue development [IGI]
- adult feeding behavior [IDA]
- bile acid metabolic process [IDA]
- bone mineralization involved in bone maturation [ISO]
- cardiac muscle hypertrophy [ISO]
- central nervous system neuron development [IMP]
- cholesterol metabolic process [IGI]
- eating behavior [IGI]
- energy reserve metabolic process [ISO]
- fatty acid beta-oxidation [IGI]
- fatty acid catabolic process [ISO]
- glucose homeostasis [IGI]
- glucose metabolic process [IMP]
- glycerol biosynthetic process [ISO]
- hormone metabolic process [IMP]
- insulin secretion [IGI]
- intracellular signal transduction [ISO]
- leptin-mediated signaling pathway [ISO]
- leukocyte tethering or rolling [ISO]
- lipid metabolic process [IMP]
- negative regulation of apoptotic process [ISO]
- negative regulation of appetite [IDA]
- negative regulation of cartilage development [ISO]
- negative regulation of glucagon secretion [IDA]
- negative regulation of glutamine transport [ISO]
- negative regulation of metabolic process [ISO]
- negative regulation of transcription from RNA polymerase II promoter [IDA]
- negative regulation of vasoconstriction [ISO]
- ovulation from ovarian follicle [ISO]
- placenta development [ISO]
- positive regulation of JAK-STAT cascade [IDA, ISO]
- positive regulation of MAPK cascade [ISO]
- positive regulation of STAT protein import into nucleus [IDA]
- positive regulation of cell proliferation [ISO]
- positive regulation of developmental growth [ISO]
- positive regulation of hepatic stellate cell activation [ISO]
- positive regulation of insulin receptor signaling pathway [ISO]
- positive regulation of ion transport [ISO]
- positive regulation of myeloid cell differentiation [IDA]
- positive regulation of peroxisome proliferator activated receptor signaling pathway [ISO]
- positive regulation of protein import into nucleus [IDA]
- positive regulation of reactive oxygen species metabolic process [ISO]
- positive regulation of tyrosine phosphorylation of Stat3 protein [ISO]
- regulation of blood pressure [ISO]
- regulation of fat cell differentiation [IGI]
- regulation of gluconeogenesis [IMP]
- regulation of insulin secretion [IMP]
- regulation of intestinal cholesterol absorption [IDA]
- regulation of lipoprotein lipid oxidation [ISO]
- regulation of metabolic process [IMP]
- regulation of protein localization to nucleus [IMP]
- regulation of protein phosphorylation [IDA]
- regulation of steroid biosynthetic process [IMP]
- response to dietary excess [IGI, IMP, ISO]
- response to insulin [IMP]
- tyrosine phosphorylation of STAT protein [IDA]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
CLU
Gene Ontology Biological Process
- cell morphogenesis [ISO]
- central nervous system myelin maintenance [ISO]
- chaperone-mediated protein complex assembly [ISO]
- chaperone-mediated protein folding [ISO]
- endocrine pancreas development [ISO]
- intrinsic apoptotic signaling pathway [ISO]
- microglial cell activation [ISO]
- microglial cell proliferation [ISO]
- negative regulation of apoptotic process [ISO]
- negative regulation of beta-amyloid formation [ISO]
- negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage [ISO]
- negative regulation of protein homooligomerization [ISO]
- neuron projection morphogenesis [ISO]
- positive regulation of NF-kappaB transcription factor activity [ISO]
- positive regulation of apoptotic process [ISO]
- positive regulation of cell differentiation [ISO]
- positive regulation of cell proliferation [ISO]
- positive regulation of intrinsic apoptotic signaling pathway [ISO]
- positive regulation of neurofibrillary tangle assembly [ISO]
- positive regulation of neuron death [ISO]
- positive regulation of nitric oxide biosynthetic process [ISO]
- positive regulation of proteasomal ubiquitin-dependent protein catabolic process [ISO]
- positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process [ISO]
- positive regulation of tau-protein kinase activity [ISO]
- positive regulation of tumor necrosis factor production [ISO]
- protein import [ISO]
- protein stabilization [ISO]
- regulation of beta-amyloid clearance [ISO]
- regulation of neuron death [ISO]
- regulation of neuronal signal transduction [ISO]
- response to misfolded protein [ISO]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
- aggresome [ISO]
- apical dendrite [ISO]
- blood microparticle [ISO]
- cytoplasm [ISO]
- extracellular matrix [ISO]
- extracellular space [ISO]
- extracellular vesicular exosome [ISO]
- growth cone [ISO]
- mitochondrion [ISO]
- neurofibrillary tangle [ISO]
- neuron projection [ISO]
- nucleus [ISO]
- perinuclear region of cytoplasm [ISO]
- spherical high-density lipoprotein particle [ISO]
Reconstituted Complex
An interaction is inferred between proteins in vitro. This can include proteins in recombinant form or proteins isolated directly from cells with recombinant or purified bait. For example, GST pull-down assays where a GST-tagged protein is first isolated and then used to fish interactors from cell lysates are considered reconstituted complexes (e.g. PUBMED: 14657240, Fig. 4A or PUBMED: 14761940, Fig. 5). This can also include gel-shifts, surface plasmon resonance, isothermal titration calorimetry (ITC) and bio-layer interferometry (BLI) experiments. The bait-hit directionality may not be clear for 2 interacting proteins. In these cases the directionality is up to the discretion of the curator.
Publication
A model for modulation of leptin activity by association with clusterin.
Transport, biological action, and clearance of leptin are subject to modulation by plasma components responsible for the formation of the so-called "bound" fraction of serum leptin. Candidates for modulators have been identified previously, but mechanisms for their action, and thus their physiological roles, have remained unclear. Here we have obtained evidence for a role of serum-borne clusterin in leptin biology ... [more]
Throughput
- Low Throughput
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| CLU LEP | Reconstituted Complex Reconstituted Complex An interaction is inferred between proteins in vitro. This can include proteins in recombinant form or proteins isolated directly from cells with recombinant or purified bait. For example, GST pull-down assays where a GST-tagged protein is first isolated and then used to fish interactors from cell lysates are considered reconstituted complexes (e.g. PUBMED: 14657240, Fig. 4A or PUBMED: 14761940, Fig. 5). This can also include gel-shifts, surface plasmon resonance, isothermal titration calorimetry (ITC) and bio-layer interferometry (BLI) experiments. The bait-hit directionality may not be clear for 2 interacting proteins. In these cases the directionality is up to the discretion of the curator. | Low | - | BioGRID | - |
Curated By
- BioGRID