BAIT
C3
AHUS5, ARMD9, ASP, C3a, C3b, CPAMD1, HEL-S-62p
complement component 3
GO Process (15)
GO Function (3)
GO Component (5)
Gene Ontology Biological Process
- G-protein coupled receptor signaling pathway [TAS]
- complement activation [IMP, TAS]
- complement activation, alternative pathway [TAS]
- immune response [TAS]
- innate immune response [TAS]
- positive regulation of G-protein coupled receptor protein signaling pathway [IDA]
- positive regulation of apoptotic cell clearance [IMP]
- positive regulation of glucose transport [IDA]
- positive regulation of lipid storage [IDA]
- positive regulation of protein phosphorylation [IDA]
- positive regulation vascular endothelial growth factor production [IDA]
- regulation of complement activation [TAS]
- regulation of immune response [TAS]
- regulation of triglyceride biosynthetic process [IDA]
- signal transduction [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
PREY
ITGB2
CD18, LAD, LCAMB, LFA-1, MAC-1, MF17, MFI7
integrin, beta 2 (complement component 3 receptor 3 and 4 subunit)
GO Process (20)
GO Function (5)
GO Component (8)
Gene Ontology Biological Process
- apoptotic process [NAS]
- blood coagulation [TAS]
- cell adhesion [TAS]
- cell-cell signaling [NAS]
- cell-matrix adhesion [IMP]
- endodermal cell differentiation [IEP]
- extracellular matrix organization [TAS]
- heterotypic cell-cell adhesion [IMP]
- inflammatory response [NAS]
- innate immune response [TAS]
- integrin-mediated signaling pathway [NAS]
- leukocyte cell-cell adhesion [IDA]
- leukocyte migration [TAS]
- neutrophil chemotaxis [IDA]
- receptor clustering [IMP]
- regulation of cell shape [NAS]
- regulation of immune response [TAS]
- regulation of peptidyl-tyrosine phosphorylation [IDA]
- toll-like receptor 4 signaling pathway [TAS]
- toll-like receptor signaling pathway [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
Reconstituted Complex
An interaction is detected between purified proteins in vitro.
Publication
Isolation of complement-fragment-iC3b-binding proteins by affinity chromatography. The identification of p150,95 as an iC3b-binding protein.
The proteins from labelled human spleen membranes and polymorphonuclear leucocytes which bind to the iC3b fragment of complement component C3 were prepared by iC3b-Sepharose chromatography in the presence of bivalent cations. Complement receptor type 3(CR3) was eluted from iC3b-Sepharose by removal of bivalent cations. Complement receptors type 1 and 2 (present in spleen but not in polymorphonuclear leucocytes) were sequentially ... [more]
Biochem. J. Oct. 01, 1985; 231(1);233-6 [Pubmed: 4062888]
Throughput
- Low Throughput
Curated By
- BioGRID