ZBTB32
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
PRDM1
Gene Ontology Biological Process
- cell fate commitment [IMP]
- embryonic placenta development [IMP]
- eye photoreceptor cell development [IMP]
- germ cell development [IGI]
- in utero embryonic development [IMP]
- intestinal epithelial cell development [IMP]
- maternal placenta development [IMP]
- negative regulation of B cell proliferation [IDA]
- negative regulation of gene expression [IMP]
- negative regulation of lipopolysaccharide-mediated signaling pathway [IDA]
- negative regulation of transcription from RNA polymerase II promoter [IDA, ISO]
- positive regulation of B cell differentiation [IDA]
- positive regulation of gene expression [IDA]
- post-embryonic development [IMP]
- transcription from RNA polymerase II promoter [ISO]
- trophoblast giant cell differentiation [IMP]
Gene Ontology Molecular Function- RNA polymerase II core promoter proximal region sequence-specific DNA binding [ISO]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription [ISO]
- histone deacetylase binding [IDA]
- protein binding [IPI]
- sequence-specific DNA binding [IDA]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding [ISO]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription [ISO]
- histone deacetylase binding [IDA]
- protein binding [IPI]
- sequence-specific DNA binding [IDA]
Affinity Capture-Western
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.
Publication
ZBTB32 is an early repressor of the CIITA and MHC class II gene expression during B cell differentiation to plasma cells.
CIITA and MHC class II expression is silenced during the differentiation of B cells to plasma cells. When B cell differentiation is carried out ex vivo, CIITA silencing occurs rapidly, but the factors contributing to this event are not known. ZBTB32, also known as repressor of GATA3, was identified as an early repressor of CIITA in an ex vivo plasma ... [more]
Throughput
- Low Throughput
Curated By
- BioGRID