KLF5
Gene Ontology Biological Process
- angiogenesis [IMP]
- intestinal epithelial cell development [IMP]
- microvillus assembly [IMP]
- negative regulation of transcription from RNA polymerase II promoter [IDA]
- positive regulation of fat cell differentiation [IMP]
- positive regulation of transcription from RNA polymerase II promoter [ISO]
- positive regulation of transcription, DNA-templated [IMP]
- regulation of microvillus assembly [IMP]
- regulation of transcription from RNA polymerase II promoter [IMP]
- skeletal muscle cell differentiation [IMP]
- transcription from RNA polymerase II promoter [ISO]
Gene Ontology Molecular Function- DNA binding [IDA, ISS]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding [ISO]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription [ISO]
- protein binding [IPI]
- sequence-specific DNA binding [ISO]
- sequence-specific DNA binding transcription factor activity [IMP]
- transcription factor binding [ISO]
- DNA binding [IDA, ISS]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding [ISO]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription [ISO]
- protein binding [IPI]
- sequence-specific DNA binding [ISO]
- sequence-specific DNA binding transcription factor activity [IMP]
- transcription factor binding [ISO]
Gene Ontology Cellular Component
MTA2
Gene Ontology Biological Process
- ATP-dependent chromatin remodeling [ISO]
- DNA methylation [IMP]
- DNA packaging [TAS]
- chromatin remodeling [TAS]
- histone deacetylation [IDA]
- negative regulation of transcription from RNA polymerase II promoter [IDA]
- negative regulation of transcription, DNA-templated [IDA]
- positive regulation of transcription from RNA polymerase II promoter [IDA]
- regulation of fibroblast migration [ISO]
Gene Ontology Molecular Function- RNA polymerase II core promoter proximal region sequence-specific DNA binding [ISO]
- RNA polymerase II distal enhancer sequence-specific DNA binding [ISO]
- RNA polymerase II repressing transcription factor binding [ISO]
- RNA polymerase II transcription factor binding [ISO]
- histone deacetylase activity [IDA]
- nucleosomal DNA binding [ISO]
- protein binding [IPI]
- transcription factor binding transcription factor activity [IDA]
- transcription regulatory region DNA binding [IDA]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding [ISO]
- RNA polymerase II distal enhancer sequence-specific DNA binding [ISO]
- RNA polymerase II repressing transcription factor binding [ISO]
- RNA polymerase II transcription factor binding [ISO]
- histone deacetylase activity [IDA]
- nucleosomal DNA binding [ISO]
- protein binding [IPI]
- transcription factor binding transcription factor activity [IDA]
- transcription regulatory region DNA binding [IDA]
Gene Ontology Cellular Component
Affinity Capture-Western
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.
Publication
Krueppel-like factor 5 is essential for blastocyst development and the normal self-renewal of mouse ESCs.
The transcription factor Klf4 has demonstrated activity in the reprogramming of somatic cells to a pluripotent state, but the molecular mechanism of this process remains unknown. It is, therefore, of great interest to understand the functional role of Klf4 and related genes in ESC regulation. Here, we show that homozygous disruption of Klf5 results in the failure of ESC derivation ... [more]
Throughput
- Low Throughput
Curated By
- BioGRID