KLF5
Gene Ontology Biological Process
- angiogenesis [IMP]
- intestinal epithelial cell development [IMP]
- microvillus assembly [IMP]
- negative regulation of transcription from RNA polymerase II promoter [IDA]
- positive regulation of fat cell differentiation [IMP]
- positive regulation of transcription from RNA polymerase II promoter [ISO]
- positive regulation of transcription, DNA-templated [IMP]
- regulation of microvillus assembly [IMP]
- regulation of transcription from RNA polymerase II promoter [IMP]
- skeletal muscle cell differentiation [IMP]
- transcription from RNA polymerase II promoter [ISO]
Gene Ontology Molecular Function- DNA binding [IDA, ISS]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding [ISO]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription [ISO]
- protein binding [IPI]
- sequence-specific DNA binding [ISO]
- sequence-specific DNA binding transcription factor activity [IMP]
- transcription factor binding [ISO]
- DNA binding [IDA, ISS]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding [ISO]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription [ISO]
- protein binding [IPI]
- sequence-specific DNA binding [ISO]
- sequence-specific DNA binding transcription factor activity [IMP]
- transcription factor binding [ISO]
Gene Ontology Cellular Component
SUMO1
Gene Ontology Biological Process
- PML body organization [IMP]
- negative regulation of DNA binding [ISO]
- negative regulation of sequence-specific DNA binding transcription factor activity [ISO]
- negative regulation of transcription, DNA-templated [ISO]
- palate development [IMP]
- positive regulation of calcium-transporting ATPase activity [IMP]
- positive regulation of proteasomal ubiquitin-dependent protein catabolic process [ISO]
- positive regulation of protein complex assembly [ISO]
- protein localization to nuclear pore [IMP]
- protein sumoylation [IDA, IMP, ISO]
- regulation of calcium ion transmembrane transport [IMP]
- regulation of cardiac muscle cell contraction [IMP]
- regulation of protein stability [IMP]
- regulation of transcription, DNA-templated [IDA]
Gene Ontology Molecular Function
Affinity Capture-Western
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.
Publication
SUMOylation regulates nuclear localization of Krueppel-like factor 5.
SUMOylation is a form of post-translational modification shown to control nuclear transport. Krueppel-like factor 5 (KLF5) is an important mediator of cell proliferation and is primarily localized to the nucleus. Here we show that mouse KLF5 is SUMOylated at lysine residues 151 and 202. Mutation of these two lysines or two conserved nearby glutamates results in the loss of SUMOylation ... [more]
Throughput
- Low Throughput
Curated By
- BioGRID