BAIT
RABGEF1
Rab5ef, Rabex5, Rin2
RAB guanine nucleotide exchange factor (GEF) 1
GO Process (13)
GO Function (4)
GO Component (2)
Gene Ontology Biological Process
- negative regulation of Kit signaling pathway [IMP]
- negative regulation of Ras protein signal transduction [IMP]
- negative regulation of inflammatory response [IMP]
- negative regulation of interleukin-6 secretion [IMP]
- negative regulation of leukocyte migration [IMP]
- negative regulation of mast cell activation [IMP]
- negative regulation of mast cell degranulation [IMP]
- negative regulation of protein phosphorylation [IMP]
- negative regulation of receptor-mediated endocytosis [IMP]
- positive regulation of Rab GTPase activity [ISO]
- protein targeting to membrane [ISO]
- protein ubiquitination [IDA]
- regulation of Fc receptor mediated stimulatory signaling pathway [IDA, IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Mus musculus
PREY
GDI2
HEL-S-46e, RABGDIB, RP11-318E3.2
GDP dissociation inhibitor 2
GO Process (3)
GO Function (2)
GO Component (5)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
Two-hybrid
Bait protein expressed as a DNA binding domain (DBD) fusion and prey expressed as a transcriptional activation domain (TAD) fusion and interaction measured by reporter gene activation.
Publication
Two-hybrid system screen with the small GTP-binding protein Rab6. Identification of a novel mouse GDP dissociation inhibitor isoform and two other potential partners of Rab6.
Rab6 is a small GTP-binding protein that belongs to the Ras superfamily and is involved in intra-Golgi transport. Using a two-hybrid system screen of a mouse brain cDNA library, we have isolated several clones encoding proteins that interact with Rab6. Approximately 60% of the clones identified encoded a new mouse Rab GDP dissociation inhibitor (GDI) isoform. This GDI isoform is ... [more]
J. Biol. Chem. Jun. 16, 1995; 270(24);14801-8 [Pubmed: 7782346]
Throughput
- Low Throughput
Curated By
- BioGRID