BAIT
FAP
DPPIV, FAPA, SIMP
fibroblast activation protein, alpha
GO Process (13)
GO Function (11)
GO Component (8)
Gene Ontology Biological Process
- endothelial cell migration [IDA]
- melanocyte apoptotic process [ISS]
- melanocyte proliferation [ISS]
- mitotic cell cycle arrest [ISS]
- negative regulation of cell proliferation involved in contact inhibition [ISS]
- negative regulation of extracellular matrix disassembly [IDA]
- negative regulation of extracellular matrix organization [IDA]
- positive regulation of cell cycle arrest [ISS]
- positive regulation of execution phase of apoptosis [ISS]
- proteolysis [IDA]
- proteolysis involved in cellular protein catabolic process [IDA]
- regulation of collagen catabolic process [IDA]
- regulation of fibrinolysis [IC]
Gene Ontology Molecular Function- dipeptidyl-peptidase activity [IDA, NAS]
- endopeptidase activity [IDA]
- integrin binding [IPI]
- metalloendopeptidase activity [TAS]
- peptidase activity [IDA]
- protease binding [IPI]
- protein binding [IPI]
- protein dimerization activity [NAS]
- protein homodimerization activity [IDA, NAS]
- serine-type endopeptidase activity [IDA]
- serine-type peptidase activity [IDA, IMP, NAS]
- dipeptidyl-peptidase activity [IDA, NAS]
- endopeptidase activity [IDA]
- integrin binding [IPI]
- metalloendopeptidase activity [TAS]
- peptidase activity [IDA]
- protease binding [IPI]
- protein binding [IPI]
- protein dimerization activity [NAS]
- protein homodimerization activity [IDA, NAS]
- serine-type endopeptidase activity [IDA]
- serine-type peptidase activity [IDA, IMP, NAS]
Gene Ontology Cellular Component
Homo sapiens
PREY
PHB
HEL-215, HEL-S-54e, PHB1
prohibitin
GO Process (15)
GO Function (4)
GO Component (8)
Gene Ontology Biological Process
- cellular response to interleukin-6 [IDA]
- histone deacetylation [IDA]
- negative regulation of androgen receptor signaling pathway [IDA, IMP]
- negative regulation of cell growth [IMP]
- negative regulation of cell proliferation [IMP]
- negative regulation of glucocorticoid receptor signaling pathway [IDA]
- negative regulation of transcription by competitive promoter binding [IDA]
- negative regulation of transcription from RNA polymerase II promoter [IDA]
- negative regulation of transcription, DNA-templated [IDA, IMP]
- osteoblast differentiation [IDA]
- positive regulation of transcription, DNA-templated [IDA]
- progesterone receptor signaling pathway [IDA]
- regulation of apoptotic process [TAS]
- regulation of transcription, DNA-templated [IDA]
- signal transduction [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
The stromal cell-surface protease fibroblast activation protein-α localizes to lipid rafts and is recruited to invadopodia.
Fibroblast activation protein alpha (FAPα) is a cell surface protease expressed by cancer-associated fibroblasts in the microenvironment of most solid tumors. As there is increasing evidence for proteases having non-catalytic functions, we determined the FAPα interactome in cancer-associated fibroblasts using the quantitative immunoprecipitation combined with knockdown (QUICK) method. Complex formation with adenosin deaminase, erlin-2, stomatin, prohibitin, Thy-1 membrane glycoprotein, and ... [more]
Biochim. Biophys. Acta Oct. 01, 2015; 1853(10);2515-25 [Pubmed: 26209915]
Throughput
- Low Throughput
Curated By
- BioGRID