BAIT
FAP
DPPIV, FAPA, SIMP
fibroblast activation protein, alpha
GO Process (13)
GO Function (11)
GO Component (8)
Gene Ontology Biological Process
- endothelial cell migration [IDA]
- melanocyte apoptotic process [ISS]
- melanocyte proliferation [ISS]
- mitotic cell cycle arrest [ISS]
- negative regulation of cell proliferation involved in contact inhibition [ISS]
- negative regulation of extracellular matrix disassembly [IDA]
- negative regulation of extracellular matrix organization [IDA]
- positive regulation of cell cycle arrest [ISS]
- positive regulation of execution phase of apoptosis [ISS]
- proteolysis [IDA]
- proteolysis involved in cellular protein catabolic process [IDA]
- regulation of collagen catabolic process [IDA]
- regulation of fibrinolysis [IC]
Gene Ontology Molecular Function- dipeptidyl-peptidase activity [IDA, NAS]
- endopeptidase activity [IDA]
- integrin binding [IPI]
- metalloendopeptidase activity [TAS]
- peptidase activity [IDA]
- protease binding [IPI]
- protein binding [IPI]
- protein dimerization activity [NAS]
- protein homodimerization activity [IDA, NAS]
- serine-type endopeptidase activity [IDA]
- serine-type peptidase activity [IDA, IMP, NAS]
- dipeptidyl-peptidase activity [IDA, NAS]
- endopeptidase activity [IDA]
- integrin binding [IPI]
- metalloendopeptidase activity [TAS]
- peptidase activity [IDA]
- protease binding [IPI]
- protein binding [IPI]
- protein dimerization activity [NAS]
- protein homodimerization activity [IDA, NAS]
- serine-type endopeptidase activity [IDA]
- serine-type peptidase activity [IDA, IMP, NAS]
Gene Ontology Cellular Component
Homo sapiens
PREY
RBM4
LARK, RBM4A, ZCCHC21, ZCRB3A, RP11-658F2.8
RNA binding motif protein 4
GO Process (14)
GO Function (8)
GO Component (6)
Gene Ontology Biological Process
- IRES-dependent translational initiation [IDA]
- RNA processing [TAS]
- cap-independent translational initiation [IDA]
- circadian regulation of translation [ISS]
- entrainment of circadian clock by photoperiod [ISS]
- negative regulation of translation [IDA]
- negative regulation of translation in response to stress [IDA]
- negative regulation of translation involved in gene silencing by miRNA [IDA]
- negative regulation of translational initiation [IDA]
- positive regulation of muscle cell differentiation [IDA]
- regulation of alternative mRNA splicing, via spliceosome [IDA]
- regulation of nucleocytoplasmic transport [IDA]
- response to arsenic-containing substance [IDA]
- stress-activated MAPK cascade [IDA]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
The stromal cell-surface protease fibroblast activation protein-α localizes to lipid rafts and is recruited to invadopodia.
Fibroblast activation protein alpha (FAPα) is a cell surface protease expressed by cancer-associated fibroblasts in the microenvironment of most solid tumors. As there is increasing evidence for proteases having non-catalytic functions, we determined the FAPα interactome in cancer-associated fibroblasts using the quantitative immunoprecipitation combined with knockdown (QUICK) method. Complex formation with adenosin deaminase, erlin-2, stomatin, prohibitin, Thy-1 membrane glycoprotein, and ... [more]
Biochim. Biophys. Acta Oct. 01, 2015; 1853(10);2515-25 [Pubmed: 26209915]
Throughput
- Low Throughput
Curated By
- BioGRID