FAP
Gene Ontology Biological Process
- endothelial cell migration [IDA]
- melanocyte apoptotic process [ISS]
- melanocyte proliferation [ISS]
- mitotic cell cycle arrest [ISS]
- negative regulation of cell proliferation involved in contact inhibition [ISS]
- negative regulation of extracellular matrix disassembly [IDA]
- negative regulation of extracellular matrix organization [IDA]
- positive regulation of cell cycle arrest [ISS]
- positive regulation of execution phase of apoptosis [ISS]
- proteolysis [IDA]
- proteolysis involved in cellular protein catabolic process [IDA]
- regulation of collagen catabolic process [IDA]
- regulation of fibrinolysis [IC]
Gene Ontology Molecular Function- dipeptidyl-peptidase activity [IDA, NAS]
- endopeptidase activity [IDA]
- integrin binding [IPI]
- metalloendopeptidase activity [TAS]
- peptidase activity [IDA]
- protease binding [IPI]
- protein binding [IPI]
- protein dimerization activity [NAS]
- protein homodimerization activity [IDA, NAS]
- serine-type endopeptidase activity [IDA]
- serine-type peptidase activity [IDA, IMP, NAS]
- dipeptidyl-peptidase activity [IDA, NAS]
- endopeptidase activity [IDA]
- integrin binding [IPI]
- metalloendopeptidase activity [TAS]
- peptidase activity [IDA]
- protease binding [IPI]
- protein binding [IPI]
- protein dimerization activity [NAS]
- protein homodimerization activity [IDA, NAS]
- serine-type endopeptidase activity [IDA]
- serine-type peptidase activity [IDA, IMP, NAS]
Gene Ontology Cellular Component
STOM
Gene Ontology Biological Process
Gene Ontology Cellular Component
Affinity Capture-Western
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.
Publication
The stromal cell-surface protease fibroblast activation protein-α localizes to lipid rafts and is recruited to invadopodia.
Fibroblast activation protein alpha (FAPα) is a cell surface protease expressed by cancer-associated fibroblasts in the microenvironment of most solid tumors. As there is increasing evidence for proteases having non-catalytic functions, we determined the FAPα interactome in cancer-associated fibroblasts using the quantitative immunoprecipitation combined with knockdown (QUICK) method. Complex formation with adenosin deaminase, erlin-2, stomatin, prohibitin, Thy-1 membrane glycoprotein, and ... [more]
Throughput
- Low Throughput
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| FAP STOM | Affinity Capture-MS Affinity Capture-MS An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods. | Low | - | BioGRID | - | |
| STOM FAP | Affinity Capture-Western Affinity Capture-Western An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins. | Low | - | BioGRID | - |
Curated By
- BioGRID