BAIT
MUS81
SLX3
MUS81 structure-specific endonuclease subunit
GO Process (3)
GO Function (2)
GO Component (2)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Homo sapiens
PREY
TRAF6
MGC:3310, RNF85
TNF receptor-associated factor 6, E3 ubiquitin protein ligase
GO Process (46)
GO Function (11)
GO Component (12)
Gene Ontology Biological Process
- Fc-epsilon receptor signaling pathway [TAS]
- I-kappaB kinase/NF-kappaB signaling [TAS]
- JNK cascade [TAS]
- MyD88-dependent toll-like receptor signaling pathway [TAS]
- MyD88-independent toll-like receptor signaling pathway [TAS]
- T cell receptor signaling pathway [IMP, TAS]
- TRIF-dependent toll-like receptor signaling pathway [TAS]
- activation of MAPK activity [TAS]
- activation of NF-kappaB-inducing kinase activity [IMP]
- activation of protein kinase activity [IDA]
- apoptotic signaling pathway [TAS]
- cellular response to lipopolysaccharide [IDA]
- innate immune response [TAS]
- membrane protein intracellular domain proteolysis [TAS]
- negative regulation of apoptotic process [TAS]
- negative regulation of transcription from RNA polymerase II promoter [IMP]
- negative regulation of transcription, DNA-templated [IMP]
- neurotrophin TRK receptor signaling pathway [TAS]
- nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway [TAS]
- nucleotide-binding oligomerization domain containing signaling pathway [TAS]
- positive regulation of I-kappaB kinase/NF-kappaB signaling [IDA, TAS]
- positive regulation of JUN kinase activity [IDA, NAS]
- positive regulation of NF-kappaB transcription factor activity [IDA, IMP, TAS]
- positive regulation of T cell activation [IC]
- positive regulation of T cell cytokine production [IMP]
- positive regulation of apoptotic process [TAS]
- positive regulation of interleukin-2 production [IMP]
- positive regulation of osteoclast differentiation [IDA]
- positive regulation of protein ubiquitination [NAS]
- positive regulation of sequence-specific DNA binding transcription factor activity [IMP]
- positive regulation of transcription from RNA polymerase II promoter [IDA, NAS]
- positive regulation of transcription regulatory region DNA binding [IDA]
- protein K63-linked ubiquitination [IDA, IGI]
- protein autoubiquitination [IDA, TAS]
- protein polyubiquitination [IDA]
- response to interleukin-1 [IDA]
- stress-activated MAPK cascade [TAS]
- toll-like receptor 10 signaling pathway [TAS]
- toll-like receptor 2 signaling pathway [TAS]
- toll-like receptor 3 signaling pathway [TAS]
- toll-like receptor 4 signaling pathway [TAS]
- toll-like receptor 5 signaling pathway [TAS]
- toll-like receptor 9 signaling pathway [TAS]
- toll-like receptor TLR1:TLR2 signaling pathway [TAS]
- toll-like receptor TLR6:TLR2 signaling pathway [TAS]
- toll-like receptor signaling pathway [TAS]
Gene Ontology Molecular Function- histone deacetylase binding [IPI]
- mitogen-activated protein kinase kinase kinase binding [IPI]
- protein N-terminus binding [IPI]
- protein binding [IPI]
- protein kinase B binding [IPI]
- protein kinase binding [IPI]
- thioesterase binding [IPI]
- tumor necrosis factor receptor binding [IPI]
- ubiquitin conjugating enzyme binding [IDA]
- ubiquitin protein ligase binding [IPI]
- ubiquitin-protein transferase activity [EXP, IDA, TAS]
- histone deacetylase binding [IPI]
- mitogen-activated protein kinase kinase kinase binding [IPI]
- protein N-terminus binding [IPI]
- protein binding [IPI]
- protein kinase B binding [IPI]
- protein kinase binding [IPI]
- thioesterase binding [IPI]
- tumor necrosis factor receptor binding [IPI]
- ubiquitin conjugating enzyme binding [IDA]
- ubiquitin protein ligase binding [IPI]
- ubiquitin-protein transferase activity [EXP, IDA, TAS]
Gene Ontology Cellular Component
Homo sapiens
Synthetic Growth Defect
A genetic interaction is inferred when mutations in separate genes, each of which alone causes a minimal phenotype, result in a significant growth defect under a given condition when combined in the same cell.
Publication
A negative genetic interaction map in isogenic cancer cell lines reveals cancer cell vulnerabilities.
Improved efforts are necessary to define the functional product of cancer mutations currently being revealed through large-scale sequencing efforts. Using genome-scale pooled shRNA screening technology, we mapped negative genetic interactions across a set of isogenic cancer cell lines and confirmed hundreds of these interactions in orthogonal co-culture competition assays to generate a high-confidence genetic interaction network of differentially essential or ... [more]
Mol. Syst. Biol. Oct. 10, 2013; 9(0);696 [Pubmed: 24104479]
Throughput
- High Throughput
Ontology Terms
- growth abnormality (HP:0001507) [hct-116 cell (BTO:0001109)]
Additional Notes
- shRNA
- siRNA
Curated By
- BioGRID