BAIT
PTEN
10q23del, BZS, CWS1, DEC, GLM2, MHAM, MMAC1, PTEN1, TEP1
phosphatase and tensin homolog
GO Process (64)
GO Function (11)
GO Component (10)
Gene Ontology Biological Process
- Fc-epsilon receptor signaling pathway [TAS]
- T cell receptor signaling pathway [TAS]
- activation of mitotic anaphase-promoting complex activity [IDA]
- apoptotic process [ISS]
- brain morphogenesis [ISS]
- canonical Wnt signaling pathway [IDA]
- cell migration [ISS]
- cell proliferation [TAS]
- central nervous system development [ISS]
- central nervous system myelin maintenance [ISS]
- central nervous system neuron axonogenesis [ISS]
- dendritic spine morphogenesis [ISS]
- dentate gyrus development [ISS]
- epidermal growth factor receptor signaling pathway [TAS]
- fibroblast growth factor receptor signaling pathway [TAS]
- forebrain morphogenesis [ISS]
- heart development [ISS]
- innate immune response [TAS]
- inositol phosphate dephosphorylation [IDA]
- inositol phosphate metabolic process [TAS]
- learning or memory [ISS]
- locomotor rhythm [ISS]
- locomotory behavior [ISS]
- multicellular organismal response to stress [ISS]
- negative regulation of G1/S transition of mitotic cell cycle [IDA]
- negative regulation of axonogenesis [ISS]
- negative regulation of cell migration [IMP]
- negative regulation of cell proliferation [IDA, IMP]
- negative regulation of cell size [ISS]
- negative regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition of mitotic cell cycle [IDA]
- negative regulation of dendritic spine morphogenesis [ISS]
- negative regulation of excitatory postsynaptic membrane potential [ISS]
- negative regulation of focal adhesion assembly [IMP]
- negative regulation of organ growth [ISS]
- negative regulation of phosphatidylinositol 3-kinase signaling [TAS]
- negative regulation of protein kinase B signaling [IMP]
- negative regulation of protein phosphorylation [IDA]
- negative regulation of synaptic vesicle clustering [ISS]
- neuron-neuron synaptic transmission [ISS]
- neurotrophin TRK receptor signaling pathway [TAS]
- peptidyl-tyrosine dephosphorylation [IDA]
- phosphatidylinositol biosynthetic process [TAS]
- phosphatidylinositol dephosphorylation [IDA, IMP]
- phosphatidylinositol-mediated signaling [TAS]
- phospholipid metabolic process [TAS]
- positive regulation of cell proliferation [ISS]
- positive regulation of excitatory postsynaptic membrane potential [ISS]
- positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process [IDA]
- positive regulation of sequence-specific DNA binding transcription factor activity [IMP]
- postsynaptic density assembly [ISS]
- prepulse inhibition [ISS]
- presynaptic membrane assembly [ISS]
- protein dephosphorylation [IDA, TAS]
- protein kinase B signaling [ISS]
- protein stabilization [IDA]
- regulation of cellular component size [ISS]
- regulation of cyclin-dependent protein serine/threonine kinase activity [TAS]
- regulation of neuron projection development [ISS]
- regulation of protein stability [IMP]
- rhythmic synaptic transmission [ISS]
- small molecule metabolic process [TAS]
- social behavior [ISS]
- synapse assembly [ISS]
- synapse maturation [ISS]
Gene Ontology Molecular Function- PDZ domain binding [IPI]
- anaphase-promoting complex binding [IPI]
- enzyme binding [IPI]
- inositol-1,3,4,5-tetrakisphosphate 3-phosphatase activity [IDA, TAS]
- phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity [IDA, TAS]
- phosphatidylinositol-3,4-bisphosphate 3-phosphatase activity [IDA, TAS]
- phosphatidylinositol-3-phosphatase activity [IDA]
- phosphoprotein phosphatase activity [IDA]
- protein binding [IPI]
- protein serine/threonine phosphatase activity [IDA]
- protein tyrosine phosphatase activity [IDA]
- PDZ domain binding [IPI]
- anaphase-promoting complex binding [IPI]
- enzyme binding [IPI]
- inositol-1,3,4,5-tetrakisphosphate 3-phosphatase activity [IDA, TAS]
- phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity [IDA, TAS]
- phosphatidylinositol-3,4-bisphosphate 3-phosphatase activity [IDA, TAS]
- phosphatidylinositol-3-phosphatase activity [IDA]
- phosphoprotein phosphatase activity [IDA]
- protein binding [IPI]
- protein serine/threonine phosphatase activity [IDA]
- protein tyrosine phosphatase activity [IDA]
Gene Ontology Cellular Component
Homo sapiens
PREY
GPER1
CEPR, CMKRL2, DRY12, FEG-1, GPCR-Br, GPER, GPR30, LERGU, LERGU2, LyGPR, mER
G protein-coupled estrogen receptor 1
GO Process (47)
GO Function (5)
GO Component (25)
Gene Ontology Biological Process
- G-protein coupled receptor signaling pathway [TAS]
- apoptotic chromosome condensation [ISS]
- cellular response to estradiol stimulus [IDA]
- cellular response to glucose stimulus [ISS]
- cellular response to mineralocorticoid stimulus [ISS]
- cellular response to peptide hormone stimulus [IDA]
- cellular response to tumor necrosis factor [IDA]
- cytosolic calcium ion homeostasis [ISS]
- intracellular steroid hormone receptor signaling pathway [IDA]
- mineralocorticoid receptor signaling pathway [ISS]
- negative regulation of DNA metabolic process [ISS]
- negative regulation of cell cycle arrest [ISS]
- negative regulation of cell proliferation [ISS]
- negative regulation of fat cell differentiation [ISS]
- negative regulation of gene expression [ISS]
- negative regulation of inflammatory response [IDA]
- negative regulation of leukocyte activation [IDA]
- negative regulation of lipid biosynthetic process [ISS]
- neuronal action potential [ISS]
- nuclear fragmentation involved in apoptotic nuclear change [ISS]
- positive regulation of ERK1 and ERK2 cascade [IDA, ISS]
- positive regulation of G-protein coupled receptor protein signaling pathway [IDA]
- positive regulation of MAPK cascade [ISS]
- positive regulation of adenylate cyclase activity involved in G-protein coupled receptor signaling pathway [IDA]
- positive regulation of apoptotic process [ISS]
- positive regulation of cAMP biosynthetic process [IDA]
- positive regulation of cell migration [IMP]
- positive regulation of cell proliferation [IMP]
- positive regulation of cysteine-type endopeptidase activity involved in apoptotic process [ISS]
- positive regulation of cytosolic calcium ion concentration [ISS]
- positive regulation of endothelial cell apoptotic process [ISS]
- positive regulation of epidermal growth factor receptor signaling pathway [IDA]
- positive regulation of establishment of protein localization to plasma membrane [IDA]
- positive regulation of extrinsic apoptotic signaling pathway [ISS]
- positive regulation of gene expression [ISS]
- positive regulation of inositol trisphosphate biosynthetic process [IDA]
- positive regulation of insulin secretion [ISS]
- positive regulation of neurogenesis [ISS]
- positive regulation of neurotransmitter secretion [ISS]
- positive regulation of phosphatidylinositol 3-kinase signaling [IDA]
- positive regulation of protein phosphorylation [IDA, ISS]
- positive regulation of release of cytochrome c from mitochondria [ISS]
- positive regulation of release of sequestered calcium ion into cytosol [IDA]
- positive regulation of transcription from RNA polymerase II promoter [IDA, ISS]
- positive regulation of uterine smooth muscle contraction [IDA]
- positive regulation of vasodilation [ISS]
- steroid hormone mediated signaling pathway [IDA]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
- Golgi apparatus [IDA]
- axon [ISS]
- axon terminus [ISS]
- cytoplasm [ISS]
- cytoplasmic vesicle membrane [IDA]
- dendrite [ISS]
- dendritic shaft [ISS]
- dendritic spine head [ISS]
- dendritic spine membrane [ISS]
- early endosome [IDA]
- endoplasmic reticulum [IDA]
- integral component of plasma membrane [TAS]
- intracellular [ISS]
- keratin filament [IDA]
- mitochondrial membrane [ISS]
- neuronal postsynaptic density [ISS]
- nuclear envelope [IDA]
- nucleus [IDA]
- perinuclear region of cytoplasm [IDA]
- plasma membrane [IDA, TAS]
- postsynaptic density [ISS]
- presynaptic active zone [ISS]
- presynaptic membrane [ISS]
- recycling endosome [IDA]
- trans-Golgi network [IDA]
Homo sapiens
Synthetic Growth Defect
A genetic interaction is inferred when mutations in separate genes, each of which alone causes a minimal phenotype, result in a significant growth defect under a given condition when combined in the same cell.
Publication
A negative genetic interaction map in isogenic cancer cell lines reveals cancer cell vulnerabilities.
Improved efforts are necessary to define the functional product of cancer mutations currently being revealed through large-scale sequencing efforts. Using genome-scale pooled shRNA screening technology, we mapped negative genetic interactions across a set of isogenic cancer cell lines and confirmed hundreds of these interactions in orthogonal co-culture competition assays to generate a high-confidence genetic interaction network of differentially essential or ... [more]
Mol. Syst. Biol. Oct. 10, 2013; 9(0);696 [Pubmed: 24104479]
Throughput
- High Throughput
Ontology Terms
- phenotype: growth abnormality (HP:0001507) [hct-116 cell (BTO:0001109)]
Additional Notes
- shRNA
- siRNA
Curated By
- BioGRID