BAIT
PTTG1
EAP1, HPTTG, PTTG, TUTR1
pituitary tumor-transforming 1
GO Process (6)
GO Function (3)
GO Component (2)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Homo sapiens
PREY
GPER1
CEPR, CMKRL2, DRY12, FEG-1, GPCR-Br, GPER, GPR30, LERGU, LERGU2, LyGPR, mER
G protein-coupled estrogen receptor 1
GO Process (47)
GO Function (5)
GO Component (25)
Gene Ontology Biological Process
- G-protein coupled receptor signaling pathway [TAS]
- apoptotic chromosome condensation [ISS]
- cellular response to estradiol stimulus [IDA]
- cellular response to glucose stimulus [ISS]
- cellular response to mineralocorticoid stimulus [ISS]
- cellular response to peptide hormone stimulus [IDA]
- cellular response to tumor necrosis factor [IDA]
- cytosolic calcium ion homeostasis [ISS]
- intracellular steroid hormone receptor signaling pathway [IDA]
- mineralocorticoid receptor signaling pathway [ISS]
- negative regulation of DNA metabolic process [ISS]
- negative regulation of cell cycle arrest [ISS]
- negative regulation of cell proliferation [ISS]
- negative regulation of fat cell differentiation [ISS]
- negative regulation of gene expression [ISS]
- negative regulation of inflammatory response [IDA]
- negative regulation of leukocyte activation [IDA]
- negative regulation of lipid biosynthetic process [ISS]
- neuronal action potential [ISS]
- nuclear fragmentation involved in apoptotic nuclear change [ISS]
- positive regulation of ERK1 and ERK2 cascade [IDA, ISS]
- positive regulation of G-protein coupled receptor protein signaling pathway [IDA]
- positive regulation of MAPK cascade [ISS]
- positive regulation of adenylate cyclase activity involved in G-protein coupled receptor signaling pathway [IDA]
- positive regulation of apoptotic process [ISS]
- positive regulation of cAMP biosynthetic process [IDA]
- positive regulation of cell migration [IMP]
- positive regulation of cell proliferation [IMP]
- positive regulation of cysteine-type endopeptidase activity involved in apoptotic process [ISS]
- positive regulation of cytosolic calcium ion concentration [ISS]
- positive regulation of endothelial cell apoptotic process [ISS]
- positive regulation of epidermal growth factor receptor signaling pathway [IDA]
- positive regulation of establishment of protein localization to plasma membrane [IDA]
- positive regulation of extrinsic apoptotic signaling pathway [ISS]
- positive regulation of gene expression [ISS]
- positive regulation of inositol trisphosphate biosynthetic process [IDA]
- positive regulation of insulin secretion [ISS]
- positive regulation of neurogenesis [ISS]
- positive regulation of neurotransmitter secretion [ISS]
- positive regulation of phosphatidylinositol 3-kinase signaling [IDA]
- positive regulation of protein phosphorylation [IDA, ISS]
- positive regulation of release of cytochrome c from mitochondria [ISS]
- positive regulation of release of sequestered calcium ion into cytosol [IDA]
- positive regulation of transcription from RNA polymerase II promoter [IDA, ISS]
- positive regulation of uterine smooth muscle contraction [IDA]
- positive regulation of vasodilation [ISS]
- steroid hormone mediated signaling pathway [IDA]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
- Golgi apparatus [IDA]
- axon [ISS]
- axon terminus [ISS]
- cytoplasm [ISS]
- cytoplasmic vesicle membrane [IDA]
- dendrite [ISS]
- dendritic shaft [ISS]
- dendritic spine head [ISS]
- dendritic spine membrane [ISS]
- early endosome [IDA]
- endoplasmic reticulum [IDA]
- integral component of plasma membrane [TAS]
- intracellular [ISS]
- keratin filament [IDA]
- mitochondrial membrane [ISS]
- neuronal postsynaptic density [ISS]
- nuclear envelope [IDA]
- nucleus [IDA]
- perinuclear region of cytoplasm [IDA]
- plasma membrane [IDA, TAS]
- postsynaptic density [ISS]
- presynaptic active zone [ISS]
- presynaptic membrane [ISS]
- recycling endosome [IDA]
- trans-Golgi network [IDA]
Homo sapiens
Synthetic Growth Defect
A genetic interaction is inferred when mutations in separate genes, each of which alone causes a minimal phenotype, result in a significant growth defect under a given condition when combined in the same cell.
Publication
A negative genetic interaction map in isogenic cancer cell lines reveals cancer cell vulnerabilities.
Improved efforts are necessary to define the functional product of cancer mutations currently being revealed through large-scale sequencing efforts. Using genome-scale pooled shRNA screening technology, we mapped negative genetic interactions across a set of isogenic cancer cell lines and confirmed hundreds of these interactions in orthogonal co-culture competition assays to generate a high-confidence genetic interaction network of differentially essential or ... [more]
Mol. Syst. Biol. Oct. 10, 2013; 9(0);696 [Pubmed: 24104479]
Throughput
- High Throughput
Ontology Terms
- phenotype: growth abnormality (HP:0001507) [hct-116 cell (BTO:0001109)]
Additional Notes
- shRNA
- siRNA
Curated By
- BioGRID