BAIT
DMRT1
CT154, DMT1
doublesex and mab-3 related transcription factor 1
GO Process (10)
GO Function (3)
GO Component (1)
Gene Ontology Biological Process
- Sertoli cell differentiation [ISS]
- male germ cell proliferation [IBA, ISS]
- male sex determination [ISS]
- male sex differentiation [ISS]
- negative regulation of meiosis [IBA, ISS]
- negative regulation of transcription from RNA polymerase II promoter [ISS]
- oocyte development [IBA]
- positive regulation of meiosis I [IBA]
- positive regulation of mitosis [ISS]
- positive regulation of transcription from RNA polymerase II promoter [ISS]
Gene Ontology Molecular Function
Homo sapiens
PREY
NANOS3
NANOS1L, NOS3
nanos homolog 3 (Drosophila)
GO Process (4)
GO Function (1)
GO Component (5)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
Phenotypic Enhancement
A genetic interaction is inferred when mutation or overexpression of one gene results in enhancement of any phenotype (other than lethality/growth defect) associated with mutation or over expression of another gene.
Publication
Interaction between DMRT1 function and genetic background modulates signaling and pluripotency to control tumor susceptibility in the fetal germ line.
Dmrt1 (doublesex and mab-3 related transcription factor (1) is a regulator of testis development in vertebrates that has been implicated in testicular germ cell tumors of mouse and human. In the fetal mouse testis Dmrt1 regulates germ cell pluripotency in a strain-dependent manner. Loss of Dmrt1 in 129Sv strain mice results in a >90% incidence of testicular teratomas, tumors consisting ... [more]
Dev. Biol. May. 01, 2013; 377(1);67-78 [Pubmed: 23473982]
Throughput
- Low Throughput
Additional Notes
- Males doubly heterozygous for Dmrt1fl and Nanos3cre had highly elevated teratoma formation
Curated By
- BioGRID