CLASP1
Gene Ontology Biological Process
- cell division [ISO]
- establishment of spindle orientation [ISO]
- exit from mitosis [ISO]
- microtubule anchoring [ISO]
- microtubule bundle formation [ISO]
- microtubule cytoskeleton organization [ISO]
- microtubule nucleation [ISO]
- microtubule organizing center organization [ISO]
- negative regulation of microtubule depolymerization [IDA, ISO]
- negative regulation of microtubule polymerization or depolymerization [ISO]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
CLIP2
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Reconstituted Complex
An interaction is inferred between proteins in vitro. This can include proteins in recombinant form or proteins isolated directly from cells with recombinant or purified bait. For example, GST pull-down assays where a GST-tagged protein is first isolated and then used to fish interactors from cell lysates are considered reconstituted complexes (e.g. PUBMED: 14657240, Fig. 4A or PUBMED: 14761940, Fig. 5). This can also include gel-shifts, surface plasmon resonance, isothermal titration calorimetry (ITC) and bio-layer interferometry (BLI) experiments. The bait-hit directionality may not be clear for 2 interacting proteins. In these cases the directionality is up to the discretion of the curator.
Publication
Clasps are CLIP-115 and -170 associating proteins involved in the regional regulation of microtubule dynamics in motile fibroblasts.
CLIP-170 and CLIP-115 are cytoplasmic linker proteins that associate specifically with the ends of growing microtubules and may act as anti-catastrophe factors. Here, we have isolated two CLIP-associated proteins (CLASPs), which are homologous to the Drosophila Orbit/Mast microtubule-associated protein. CLASPs bind CLIPs and microtubules, colocalize with the CLIPs at microtubule distal ends, and have microtubule-stabilizing effects in transfected cells. After ... [more]
Throughput
- Low Throughput
Additional Notes
- Figure 3E
Curated By
- BioGRID