Negative Genetic
Mutations/deletions in separate genes, each of which alone causes a minimal phenotype, but when combined in the same cell results in a more severe fitness defect or lethality under a given condition. This term is reserved for high or low throughput studies with scores.
Publication
Genetic interaction maps in Escherichia coli reveal functional crosstalk among cell envelope biogenesis pathways.
As the interface between a microbe and its environment, the bacterial cell envelope has broad biological and clinical significance. While numerous biosynthesis genes and pathways have been identified and studied in isolation, how these intersect functionally to ensure envelope integrity during adaptive responses to environmental challenge remains unclear. To this end, we performed high-density synthetic genetic screens to generate quantitative ... [more]
Quantitative Score
- -20.0000002 [Confidence Score]
Throughput
- High Throughput
Additional Notes
- Conditions: rich growth medium
- Genetic interactions were considered significant if they had an E-score >= 2.0 for positive interactions (alleviating interactions) and E-score <= -2.0 for negative interactions (aggravating interactions).
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| AGAS DDLA | Negative Genetic Negative Genetic Mutations/deletions in separate genes, each of which alone causes a minimal phenotype, but when combined in the same cell results in a more severe fitness defect or lethality under a given condition. This term is reserved for high or low throughput studies with scores. | High | -5.5665 | BioGRID | 1409592 |
Curated By
- BioGRID