ITGB2
Gene Ontology Biological Process
- apoptotic process [NAS]
- blood coagulation [TAS]
- cell adhesion [TAS]
- cell-cell signaling [NAS]
- cell-matrix adhesion [IMP]
- endodermal cell differentiation [IEP]
- extracellular matrix organization [TAS]
- heterotypic cell-cell adhesion [IMP]
- inflammatory response [NAS]
- innate immune response [TAS]
- integrin-mediated signaling pathway [NAS]
- leukocyte cell-cell adhesion [IDA]
- leukocyte migration [TAS]
- neutrophil chemotaxis [IDA]
- receptor clustering [IMP]
- regulation of cell shape [NAS]
- regulation of immune response [TAS]
- regulation of peptidyl-tyrosine phosphorylation [IDA]
- toll-like receptor 4 signaling pathway [TAS]
- toll-like receptor signaling pathway [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
GNB2L1
Gene Ontology Biological Process
- activation of cysteine-type endopeptidase activity involved in apoptotic process [IMP]
- negative regulation of Wnt signaling pathway [ISS]
- negative regulation of cell growth [IDA]
- negative regulation of gene expression [IMP]
- negative regulation of hydrogen peroxide-induced neuron death [IGI]
- negative regulation of phagocytosis [IMP]
- negative regulation of protein kinase B signaling [IMP]
- negative regulation of protein tyrosine kinase activity [IDA]
- negative regulation of translation [ISS]
- positive regulation of GTPase activity [IDA]
- positive regulation of apoptotic process [IDA, IMP]
- positive regulation of cAMP catabolic process [IMP]
- positive regulation of cell migration [IDA]
- positive regulation of cyclic-nucleotide phosphodiesterase activity [IMP]
- positive regulation of gastrulation [ISS]
- positive regulation of intrinsic apoptotic signaling pathway [IMP]
- positive regulation of mitochondrial depolarization [IMP]
- positive regulation of proteasomal ubiquitin-dependent protein catabolic process [IDA]
- positive regulation of protein homooligomerization [IDA, IMP]
- positive regulation of protein phosphorylation [IDA]
- regulation of cell cycle [IDA]
- regulation of cell division [ISS]
- regulation of establishment of cell polarity [ISS]
- regulation of protein localization [ISS]
Gene Ontology Molecular Function- SH2 domain binding [IDA]
- cysteine-type endopeptidase activator activity involved in apoptotic process [IMP]
- enzyme binding [IPI]
- ion channel inhibitor activity [ISS]
- poly(A) RNA binding [IDA]
- protein binding [IPI]
- protein complex scaffold [TAS]
- protein homodimerization activity [IDA]
- protein kinase C binding [IDA]
- protein phosphatase binding [IPI]
- protein tyrosine kinase inhibitor activity [IDA]
- receptor binding [NAS]
- receptor tyrosine kinase binding [IDA]
- SH2 domain binding [IDA]
- cysteine-type endopeptidase activator activity involved in apoptotic process [IMP]
- enzyme binding [IPI]
- ion channel inhibitor activity [ISS]
- poly(A) RNA binding [IDA]
- protein binding [IPI]
- protein complex scaffold [TAS]
- protein homodimerization activity [IDA]
- protein kinase C binding [IDA]
- protein phosphatase binding [IPI]
- protein tyrosine kinase inhibitor activity [IDA]
- receptor binding [NAS]
- receptor tyrosine kinase binding [IDA]
Gene Ontology Cellular Component
Two-hybrid
Bait protein expressed as a DNA binding domain (DBD) fusion and prey expressed as a transcriptional activation domain (TAD) fusion and interaction measured by reporter gene activation.
Publication
Rack1, a receptor for activated protein kinase C, interacts with integrin beta subunit.
The integrin beta subunit cytoplasmic domains are important for activation-dependent cell adhesion and adhesion-dependent signaling events. We report an interaction between integrin beta subunit cytoplasmic domain and Rack1, a Trp-Asp (WD) repeat protein that has been shown to bind activated protein kinase C. The Rack1-binding site on integrin beta 2 subunit resides within a conserved, membrane-proximal region. In the yeast ... [more]
Throughput
- Low Throughput
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| ITGB2 GNB2L1 | Affinity Capture-Western Affinity Capture-Western An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins. | Low | - | BioGRID | - | |
| ITGB2 GNB2L1 | Reconstituted Complex Reconstituted Complex An interaction is inferred between proteins in vitro. This can include proteins in recombinant form or proteins isolated directly from cells with recombinant or purified bait. For example, GST pull-down assays where a GST-tagged protein is first isolated and then used to fish interactors from cell lysates are considered reconstituted complexes (e.g. PUBMED: 14657240, Fig. 4A or PUBMED: 14761940, Fig. 5). This can also include gel-shifts, surface plasmon resonance, isothermal titration calorimetry (ITC) and bio-layer interferometry (BLI) experiments. The bait-hit directionality may not be clear for 2 interacting proteins. In these cases the directionality is up to the discretion of the curator. | Low | - | BioGRID | - |
Curated By
- BioGRID