BAIT
KRIT1
CAM, CCM1
KRIT1, ankyrin repeat containing
GO Process (8)
GO Function (5)
GO Component (4)
Gene Ontology Biological Process
- cell redox homeostasis [IMP]
- negative regulation of angiogenesis [IMP]
- negative regulation of endothelial cell apoptotic process [IMP]
- negative regulation of endothelial cell migration [IMP]
- negative regulation of endothelial cell proliferation [IMP]
- regulation of catalytic activity [TAS]
- regulation of establishment of cell polarity [IMP]
- small GTPase mediated signal transduction [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
PREY
RAP1A
C21KG, G-22K, KREV-1, KREV1, RAP1, SMGP21
RAP1A, member of RAS oncogene family
GO Process (20)
GO Function (4)
GO Component (8)
Gene Ontology Biological Process
- Rap protein signal transduction [IMP]
- activation of MAPKK activity [TAS]
- blood coagulation [TAS]
- cellular response to cAMP [IDA]
- cellular response to nerve growth factor stimulus [ISS]
- energy reserve metabolic process [TAS]
- establishment of endothelial barrier [IMP]
- nerve growth factor signaling pathway [ISS]
- neurotrophin TRK receptor signaling pathway [TAS]
- platelet activation [TAS]
- positive regulation of ERK1 and ERK2 cascade [ISS]
- positive regulation of Rap GTPase activity [ISS]
- positive regulation of neuron projection development [ISS]
- positive regulation of protein kinase activity [ISS]
- positive regulation of vasculogenesis [ISS]
- protein transport [IDA]
- regulation of cell junction assembly [IMP]
- regulation of insulin secretion [TAS]
- signal transduction [TAS]
- small molecule metabolic process [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
Two-hybrid
Bait protein expressed as a DNA binding domain (DBD) fusion and prey expressed as a transcriptional activation domain (TAD) fusion and interaction measured by reporter gene activation.
Publication
Association of Krev-1/rap1a with Krit1, a novel ankyrin repeat-containing protein encoded by a gene mapping to 7q21-22.
Krev-1/rap1A is an evolutionarily conserved Ras-family GTPase whose cellular function remains unclear, but which has been proposed to function as a tumor suppressor gene, and may act as a Ras antagonist. To elucidate Krev-1 activity, we have used LexA-Krev-1 in a two-hybrid screen of a HeLa cell cDNA library. Of the two cDNA classes isolated, one contained a single isolate ... [more]
Oncogene Aug. 28, 1997; 15(9);1043-9 [Pubmed: 9285558]
Throughput
- Low Throughput
Curated By
- BioGRID