BAIT
KRAS
C-K-RAS, CFC2, K-RAS2A, K-RAS2B, K-RAS4A, K-RAS4B, KI-RAS, KRAS1, KRAS2, NS, NS3, RASK2
Kirsten rat sarcoma viral oncogene homolog
GO Process (16)
GO Function (2)
GO Component (5)
Gene Ontology Biological Process
- Fc-epsilon receptor signaling pathway [TAS]
- MAPK cascade [TAS]
- Ras protein signal transduction [TAS]
- activation of MAPKK activity [TAS]
- axon guidance [TAS]
- blood coagulation [TAS]
- epidermal growth factor receptor signaling pathway [TAS]
- fibroblast growth factor receptor signaling pathway [TAS]
- innate immune response [TAS]
- insulin receptor signaling pathway [TAS]
- leukocyte migration [TAS]
- neurotrophin TRK receptor signaling pathway [TAS]
- positive regulation of cell proliferation [IMP]
- positive regulation of gene expression [IMP]
- positive regulation of protein phosphorylation [IMP]
- small GTPase mediated signal transduction [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
PREY
RGCC
C13orf15, RGC-32, RGC32, bA157L14.2
regulator of cell cycle
GO Process (25)
GO Function (4)
GO Component (3)
Gene Ontology Biological Process
- cellular response to hypoxia [IMP]
- complement activation [IMP]
- fibroblast activation [ISS]
- mitotic cell cycle arrest [IDA]
- negative regulation of angiogenesis [IDA]
- negative regulation of blood vessel endothelial cell migration [IDA]
- negative regulation of cell proliferation [IMP]
- negative regulation of cell-cell adhesion mediated by cadherin [IDA]
- negative regulation of cytokine secretion [IMP]
- negative regulation of endothelial cell proliferation [IDA]
- negative regulation of exit from mitosis [IDA]
- negative regulation of fibroblast growth factor production [IDA]
- negative regulation of mitotic cell cycle phase transition [IDA]
- positive regulation of DNA biosynthetic process [ISS]
- positive regulation of cell cycle arrest [IDA]
- positive regulation of collagen biosynthetic process [IDA]
- positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition of mitotic cell cycle [IDA]
- positive regulation of cytokine secretion [IMP]
- positive regulation of endothelial cell apoptotic process [IDA]
- positive regulation of epithelial to mesenchymal transition [IDA, IMP]
- positive regulation of extracellular matrix constituent secretion [IDA]
- positive regulation of gene expression [IDA]
- positive regulation of mitosis [IMP]
- positive regulation of sequence-specific DNA binding transcription factor activity [IMP]
- positive regulation of stress fiber assembly [IDA]
Gene Ontology Molecular Function
Homo sapiens
Synthetic Lethality
A genetic interaction is inferred when mutations or deletions in separate genes, each of which alone causes a minimal phenotype, result in lethality when combined in the same cell under a given condition.
Publication
A genome-wide RNAi screen identifies multiple synthetic lethal interactions with the Ras oncogene.
Oncogenic mutations in the small GTPase Ras are highly prevalent in cancer, but an understanding of the vulnerabilities of these cancers is lacking. We undertook a genome-wide RNAi screen to identify synthetic lethal interactions with the KRAS oncogene. We discovered a diverse set of proteins whose depletion selectively impaired the viability of Ras mutant cells. Among these we observed a ... [more]
Cell May. 29, 2009; 137(5);835-48 [Pubmed: 19490893]
Throughput
- High Throughput
Ontology Terms
- phenotype: growth abnormality (HP:0001507)
Additional Notes
- RNAi screen
Curated By
- BioGRID