BAIT
KRAS
C-K-RAS, CFC2, K-RAS2A, K-RAS2B, K-RAS4A, K-RAS4B, KI-RAS, KRAS1, KRAS2, NS, NS3, RASK2
Kirsten rat sarcoma viral oncogene homolog
GO Process (16)
GO Function (2)
GO Component (5)
Gene Ontology Biological Process
- Fc-epsilon receptor signaling pathway [TAS]
- MAPK cascade [TAS]
- Ras protein signal transduction [TAS]
- activation of MAPKK activity [TAS]
- axon guidance [TAS]
- blood coagulation [TAS]
- epidermal growth factor receptor signaling pathway [TAS]
- fibroblast growth factor receptor signaling pathway [TAS]
- innate immune response [TAS]
- insulin receptor signaling pathway [TAS]
- leukocyte migration [TAS]
- neurotrophin TRK receptor signaling pathway [TAS]
- positive regulation of cell proliferation [IMP]
- positive regulation of gene expression [IMP]
- positive regulation of protein phosphorylation [IMP]
- small GTPase mediated signal transduction [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
PREY
SLC11A2
DCT1, DMT1, NRAMP2, OK/SW-cl.20
solute carrier family 11 (proton-coupled divalent metal ion transporter), member 2
GO Process (22)
GO Function (14)
GO Component (19)
Gene Ontology Biological Process
- activation of cysteine-type endopeptidase activity involved in apoptotic process [IDA]
- cadmium ion transmembrane transport [IDA]
- cation transmembrane transport [IGI]
- cellular iron ion homeostasis [TAS]
- cellular response to oxidative stress [IDA]
- cobalt ion transport [IDA]
- copper ion transmembrane transport [IDA]
- copper ion transport [IDA]
- detection of oxygen [IEP]
- ferrous iron import [IDA]
- ferrous iron transport [IDA]
- lead ion transport [IDA]
- manganese ion transmembrane transport [IDA]
- manganese ion transport [IDA]
- multicellular organismal iron ion homeostasis [IMP]
- nickel cation transmembrane transport [IDA]
- nickel cation transport [IDA]
- response to hypoxia [IEP]
- response to iron ion [IEP]
- transmembrane transport [TAS]
- vanadium ion transport [IDA]
- zinc ion transmembrane transport [IDA]
Gene Ontology Molecular Function- cadmium ion transmembrane transporter activity [IDA]
- calcium ion transmembrane transporter activity [IDA]
- chromium ion transmembrane transporter activity [IDA]
- cobalt ion transmembrane transporter activity [IDA]
- copper ion transmembrane transporter activity [IDA]
- ferrous iron transmembrane transporter activity [IDA]
- inorganic cation transmembrane transporter activity [IGI]
- lead ion transmembrane transporter activity [IDA]
- manganese ion transmembrane transporter activity [IDA]
- nickel cation transmembrane transporter activity [IDA]
- protein binding [IPI]
- solute:proton symporter activity [IDA]
- vanadium ion transmembrane transporter activity [IDA]
- zinc ion transmembrane transporter activity [IDA]
- cadmium ion transmembrane transporter activity [IDA]
- calcium ion transmembrane transporter activity [IDA]
- chromium ion transmembrane transporter activity [IDA]
- cobalt ion transmembrane transporter activity [IDA]
- copper ion transmembrane transporter activity [IDA]
- ferrous iron transmembrane transporter activity [IDA]
- inorganic cation transmembrane transporter activity [IGI]
- lead ion transmembrane transporter activity [IDA]
- manganese ion transmembrane transporter activity [IDA]
- nickel cation transmembrane transporter activity [IDA]
- protein binding [IPI]
- solute:proton symporter activity [IDA]
- vanadium ion transmembrane transporter activity [IDA]
- zinc ion transmembrane transporter activity [IDA]
Gene Ontology Cellular Component
- apical part of cell [IDA]
- apical plasma membrane [IDA]
- basal part of cell [IDA]
- cell surface [IDA]
- cytoplasm [IDA]
- cytoplasmic vesicle [IDA]
- early endosome [IDA]
- late endosome [IDA]
- late endosome membrane [IDA]
- lysosomal membrane [IDA]
- lysosome [IDA]
- membrane [IDA]
- nucleus [IDA]
- paraferritin complex [IDA]
- perinuclear region of cytoplasm [IDA]
- plasma membrane [IDA, IMP, TAS]
- recycling endosome [IDA]
- trans-Golgi network [IDA]
- vacuole [IMP]
Homo sapiens
Synthetic Lethality
A genetic interaction is inferred when mutations or deletions in separate genes, each of which alone causes a minimal phenotype, result in lethality when combined in the same cell under a given condition.
Publication
A genome-wide RNAi screen identifies multiple synthetic lethal interactions with the Ras oncogene.
Oncogenic mutations in the small GTPase Ras are highly prevalent in cancer, but an understanding of the vulnerabilities of these cancers is lacking. We undertook a genome-wide RNAi screen to identify synthetic lethal interactions with the KRAS oncogene. We discovered a diverse set of proteins whose depletion selectively impaired the viability of Ras mutant cells. Among these we observed a ... [more]
Cell May. 29, 2009; 137(5);835-48 [Pubmed: 19490893]
Throughput
- High Throughput
Ontology Terms
- phenotype: growth abnormality (HP:0001507)
Additional Notes
- RNAi screen
Curated By
- BioGRID