BAIT
KRAS
C-K-RAS, CFC2, K-RAS2A, K-RAS2B, K-RAS4A, K-RAS4B, KI-RAS, KRAS1, KRAS2, NS, NS3, RASK2
Kirsten rat sarcoma viral oncogene homolog
GO Process (16)
GO Function (2)
GO Component (5)
Gene Ontology Biological Process
- Fc-epsilon receptor signaling pathway [TAS]
- MAPK cascade [TAS]
- Ras protein signal transduction [TAS]
- activation of MAPKK activity [TAS]
- axon guidance [TAS]
- blood coagulation [TAS]
- epidermal growth factor receptor signaling pathway [TAS]
- fibroblast growth factor receptor signaling pathway [TAS]
- innate immune response [TAS]
- insulin receptor signaling pathway [TAS]
- leukocyte migration [TAS]
- neurotrophin TRK receptor signaling pathway [TAS]
- positive regulation of cell proliferation [IMP]
- positive regulation of gene expression [IMP]
- positive regulation of protein phosphorylation [IMP]
- small GTPase mediated signal transduction [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
PREY
TWIST1
ACS3, BPES2, BPES3, CRS, CRS1, CSO, SCS, TWIST, bHLHa38
twist family bHLH transcription factor 1
GO Process (30)
GO Function (5)
GO Component (1)
Gene Ontology Biological Process
- aortic valve morphogenesis [IMP]
- cell proliferation involved in heart valve development [IMP]
- cellular response to hypoxia [IMP]
- cranial suture morphogenesis [TAS]
- embryonic camera-type eye formation [IMP]
- embryonic cranial skeleton morphogenesis [IMP]
- embryonic digit morphogenesis [TAS]
- eyelid development in camera-type eye [IMP]
- negative regulation of DNA damage response, signal transduction by p53 class mediator [IMP]
- negative regulation of cellular senescence [IMP]
- negative regulation of double-strand break repair [IMP]
- negative regulation of histone phosphorylation [IMP]
- negative regulation of osteoblast differentiation [IMP]
- negative regulation of phosphatidylinositol 3-kinase signaling [IMP]
- negative regulation of transcription from RNA polymerase II promoter [IMP]
- negative regulation of transcription, DNA-templated [ISS]
- ossification [TAS]
- outer ear morphogenesis [TAS]
- positive regulation of angiogenesis [NAS]
- positive regulation of cell motility [IMP, NAS]
- positive regulation of epithelial to mesenchymal transition [IMP]
- positive regulation of fatty acid beta-oxidation [IMP]
- positive regulation of gene expression [IMP]
- positive regulation of interleukin-6 secretion [IMP]
- positive regulation of monocyte chemotactic protein-1 production [IMP]
- positive regulation of transcription from RNA polymerase II promoter [IDA, IMP]
- positive regulation of transcription regulatory region DNA binding [IMP]
- positive regulation of tumor necrosis factor production [IMP]
- regulation of bone mineralization [IMP]
- transcription from RNA polymerase II promoter [IDA]
Gene Ontology Molecular Function
Homo sapiens
Synthetic Lethality
A genetic interaction is inferred when mutations or deletions in separate genes, each of which alone causes a minimal phenotype, result in lethality when combined in the same cell under a given condition.
Publication
A genome-wide RNAi screen identifies multiple synthetic lethal interactions with the Ras oncogene.
Oncogenic mutations in the small GTPase Ras are highly prevalent in cancer, but an understanding of the vulnerabilities of these cancers is lacking. We undertook a genome-wide RNAi screen to identify synthetic lethal interactions with the KRAS oncogene. We discovered a diverse set of proteins whose depletion selectively impaired the viability of Ras mutant cells. Among these we observed a ... [more]
Cell May. 29, 2009; 137(5);835-48 [Pubmed: 19490893]
Throughput
- High Throughput
Ontology Terms
- phenotype: growth abnormality (HP:0001507)
Additional Notes
- RNAi screen
Curated By
- BioGRID