RIMS1
Gene Ontology Biological Process
- calcium ion-dependent exocytosis of neurotransmitter [IGI]
- long-term synaptic potentiation [ISO]
- positive regulation of inhibitory postsynaptic membrane potential [ISO]
- positive regulation of synaptic vesicle priming [ISO]
- protein complex assembly [ISO]
- regulation of long-term neuronal synaptic plasticity [IMP]
- regulation of membrane potential [IDA]
- regulation of synaptic vesicle exocytosis [ISO]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
RAB10
Gene Ontology Biological Process
- GTP catabolic process [IBA, ISO]
- Golgi to plasma membrane transport [ISO]
- Rab protein signal transduction [IBA]
- antigen processing and presentation [ISO]
- axonogenesis [ISO]
- cellular response to insulin stimulus [IMP]
- endoplasmic reticulum tubular network organization [ISO]
- endosomal transport [ISO]
- establishment of neuroblast polarity [ISO]
- establishment of protein localization to endoplasmic reticulum membrane [ISO]
- establishment of protein localization to membrane [ISO]
- intracellular protein transport [TAS]
- protein localization to plasma membrane [IMP]
- protein secretion [IBA]
- regulation of exocytosis [IBA]
- vesicle docking involved in exocytosis [IBA]
- vesicle-mediated transport [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
- Golgi apparatus [IDA, ISO]
- cell [TAS]
- endoplasmic reticulum membrane [ISO]
- endoplasmic reticulum tubular network [ISO]
- endosome [ISO]
- endosome membrane [IBA]
- extracellular vesicular exosome [ISO]
- focal adhesion [ISO]
- insulin-responsive compartment [IBA, ISO]
- intracellular [TAS]
- membrane [ISO]
- perinuclear region of cytoplasm [ISO]
- plasma membrane [ISO]
- primary cilium [IDA, ISO]
- recycling endosome [ISO]
- trans-Golgi network [ISO]
Affinity Capture-Western
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.
Publication
Distinct Rab binding specificity of Rim1, Rim2, rabphilin, and Noc2. Identification of a critical determinant of Rab3A/Rab27A recognition by Rim2.
Rabphilin, Rim, and Noc2 have generally been believed to be the Rab3 isoform (Rab3A/B/C/D)-specific effectors that regulate secretory vesicle exocytosis in neurons and in some endocrine cells. The results of recent genetic analysis of rabphilin knock-out animals, however, strongly refute this notion, because there are no obvious genetic interactions between Rab3 and rabphilin in nematoda (Staunton, J., Ganetzky, B., and ... [more]
Throughput
- Low Throughput
Additional Notes
- Figure 5
Curated By
- BioGRID