BAIT

CTDP1

CCFDN, FCP1
CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) phosphatase, subunit 1
Homo sapiens
PREY

CSNK2A2

CK2A2, CSNK2A1
casein kinase 2, alpha prime polypeptide
GO Process (3)
GO Function (2)
GO Component (3)

Gene Ontology Biological Process

Gene Ontology Molecular Function

Gene Ontology Cellular Component

Homo sapiens

Affinity Capture-MS

An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.

Publication

The C-terminal domain phosphatase and transcription elongation activities of FCP1 are regulated by phosphorylation.

Friedl EM, Lane WS, Erdjument-Bromage H, Tempst P, Reinberg D

The C-terminal domain (CTD) of the largest subunit of RNA polymerase II (RNAPII) is heavily phosphorylated during the transition from transcription initiation to the establishment of an elongation-competent transcription complex. FCP1 is the only phosphatase known to be specific for the CTD of the largest subunit of RNAPII, and its activity is believed to be required to reactivate RNAPII, so ... [more]

Proc. Natl. Acad. Sci. U.S.A. Mar. 04, 2003; 100(5);2328-33 [Pubmed: 12591939]

Throughput

  • Low Throughput

Curated By

  • BioGRID