BAIT
HOMER1
HOMER, HOMER1A, HOMER1B, HOMER1C, SYN47, Ves-1
homer homolog 1 (Drosophila)
GO Process (6)
GO Function (3)
GO Component (1)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
PREY
GRM1
Gprc1a
glutamate receptor, metabotropic 1
GO Process (19)
GO Function (6)
GO Component (10)
Gene Ontology Biological Process
- G-protein coupled glutamate receptor signaling pathway [IBA, ISO, ISS]
- G-protein coupled receptor signaling pathway [ISO, ISS]
- activation of MAPK activity [ISO]
- activation of MAPKK activity [ISO]
- calcium-mediated signaling [IDA]
- cellular response to electrical stimulus [ISO]
- dimeric G-protein coupled receptor signaling pathway [ISO, ISS]
- locomotory behavior [ISO]
- membrane depolarization [TAS]
- phospholipase C-activating G-protein coupled glutamate receptor signaling pathway [TAS]
- positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathway [ISO, ISS, TAS]
- protein kinase C-activating G-protein coupled receptor signaling pathway [IBA]
- regulation of MAPK cascade [ISO]
- regulation of glutamate secretion [TAS]
- regulation of sensory perception of pain [ISO]
- regulation of synaptic transmission, glutamatergic [IDA]
- sensory perception of pain [IEP, ISO]
- synaptic transmission [IEP]
- synaptic transmission, GABAergic [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Rattus norvegicus
Reconstituted Complex
An interaction is detected between purified proteins in vitro.
Publication
Homer: a protein that selectively binds metabotropic glutamate receptors.
Spatial localization and clustering of membrane proteins is critical to neuronal development and synaptic plasticity. Recent studies have identified a family of proteins, the PDZ proteins, that contain modular PDZ domains and interact with synaptic ionotropic glutamate receptors and ion channels. PDZ proteins are thought to have a role in defining the cellular distribution of the proteins that interact with ... [more]
Nature Mar. 20, 1997; 386(6622);284-8 [Pubmed: 9069287]
Throughput
- Low Throughput
Curated By
- BioGRID