Bait protein expressed as a DNA binding domain (DBD) fusion and prey expressed as a transcriptional activation domain (TAD) fusion and interaction measured by reporter gene activation.

Publication

The class III POU factor Brn-4 interacts with other class III POU factors and the heterogeneous nuclear ribonucleoprotein U.

Malik KF, Jaffe H, Brady J, Young WS

The class III POU proteins are expressed throughout the central nervous system, including the hypothalamus, where they are often co-localized. Presumably, these POU proteins (Brain-1, Brain-2, Brain-4 and SCIP) serve as transcriptional transactivators. That they are co-expressed in some neurons suggests that, if they were to form homomeric and heteromeric complexes with each other, depending on the particular combination, they ... [more]

Brain Res. Mol. Brain Res. Apr. 01, 1997; 45(1);99-107 [Pubmed: 9105675]

Throughput

Low Throughput

Related interactions

Interaction	Experimental Evidence Code	Dataset	Throughput	Score	Curated By	Notes
POU3F4 POU3F4	Far Western Far Western An interaction is detected between a protein immobilized on a membrane and a purified protein probe.	Malik KF (1997)	Low	-	BioGRID	-

Curated By

BioGRID

Interaction Summary

POU3F4

Gene Ontology Biological Process

Gene Ontology Molecular Function

AT DNA binding [IDA]RNA polymerase II regulatory region sequence-specific DNA binding [ISO]double-stranded DNA binding [IDA]sequence-specific DNA binding [ISO]sequence-specific DNA binding transcription factor activity [IDA]

Gene Ontology Cellular Component