ODC1
Gene Ontology Biological Process
Gene Ontology Molecular Function
OAZ2
Gene Ontology Biological Process
- cellular nitrogen compound metabolic process [TAS]
- negative regulation of catalytic activity [IDA, TAS]
- polyamine metabolic process [TAS]
- positive regulation of intracellular protein transport [ISS]
- positive regulation of protein catabolic process [ISS]
- regulation of cellular amino acid metabolic process [TAS]
- small molecule metabolic process [TAS]
Gene Ontology Molecular Function
Reconstituted Complex
An interaction is inferred between proteins in vitro. This can include proteins in recombinant form or proteins isolated directly from cells with recombinant or purified bait. For example, GST pull-down assays where a GST-tagged protein is first isolated and then used to fish interactors from cell lysates are considered reconstituted complexes (e.g. PUBMED: 14657240, Fig. 4A or PUBMED: 14761940, Fig. 5). This can also include gel-shifts, surface plasmon resonance, isothermal titration calorimetry (ITC) and bio-layer interferometry (BLI) experiments. The bait-hit directionality may not be clear for 2 interacting proteins. In these cases the directionality is up to the discretion of the curator.
Publication
Structural elements of antizymes 1 and 2 are required for proteasomal degradation of ornithine decarboxylase.
The antizymes constitute a conserved gene family with at least three mammalian orthologs. As described previously, in a degradation system utilizing rabbit reticulocyte lysate, antizyme 1 (AZ1) accelerates proteasomal ornithine decarboxylase (ODC) degradation, but antizyme 2 (AZ2) does not. To examine the relationship between antizyme structure and function, we further characterized the properties of AZ1 and AZ2 and protein chimeras ... [more]
Throughput
- Low Throughput
Curated By
- BioGRID