GRIN2D
Gene Ontology Biological Process
- adult locomotory behavior [ISO]
- cation transmembrane transport [IDA]
- cation transport [IDA]
- detection of mechanical stimulus involved in sensory perception of pain [ISO]
- ion transmembrane transport [IBA, ISO]
- ionotropic glutamate receptor signaling pathway [IDA, IMP, ISO]
- regulation of excitatory postsynaptic membrane potential [ISO]
- regulation of ion transmembrane transport [IMP]
- regulation of sensory perception of pain [ISO]
- startle response [ISO]
- synaptic transmission, glutamatergic [IMP]
Gene Ontology Molecular Function- N-methyl-D-aspartate selective glutamate receptor activity [IDA, IMP, ISO]
- cation channel activity [IDA]
- extracellular-glutamate-gated ion channel activity [IBA]
- glutamate binding [IMP]
- ionotropic glutamate receptor activity [IDA]
- neurotransmitter binding [IMP]
- protein binding [IPI]
- voltage-gated cation channel activity [IMP]
- N-methyl-D-aspartate selective glutamate receptor activity [IDA, IMP, ISO]
- cation channel activity [IDA]
- extracellular-glutamate-gated ion channel activity [IBA]
- glutamate binding [IMP]
- ionotropic glutamate receptor activity [IDA]
- neurotransmitter binding [IMP]
- protein binding [IPI]
- voltage-gated cation channel activity [IMP]
Gene Ontology Cellular Component
IL16
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Reconstituted Complex
An interaction is inferred between proteins in vitro. This can include proteins in recombinant form or proteins isolated directly from cells with recombinant or purified bait. For example, GST pull-down assays where a GST-tagged protein is first isolated and then used to fish interactors from cell lysates are considered reconstituted complexes (e.g. PUBMED: 14657240, Fig. 4A or PUBMED: 14761940, Fig. 5). This can also include gel-shifts, surface plasmon resonance, isothermal titration calorimetry (ITC) and bio-layer interferometry (BLI) experiments. The bait-hit directionality may not be clear for 2 interacting proteins. In these cases the directionality is up to the discretion of the curator.
Publication
Neuronal interleukin-16 (NIL-16): a dual function PDZ domain protein.
Interleukin (IL)-16 is a proinflammatory cytokine that has attracted widespread attention because of its ability to block HIV replication. We describe the identification and characterization of a large neuronal IL-16 precursor, NIL-16. The N-terminal half of NIL-16 constitutes a novel PDZ domain protein sequence, whereas the C terminus is identical with splenocyte-derived mouse pro-IL-16. IL-16 has been characterized only in ... [more]
Throughput
- Low Throughput
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| IL16 GRIN2D | Two-hybrid Two-hybrid Bait protein expressed as a DNA binding domain (DBD) fusion and prey expressed as a transcriptional activation domain (TAD) fusion and interaction measured by reporter gene activation. | Low | - | BioGRID | - |
Curated By
- BioGRID