Publication

Contribution of the different modules in the utrophin carboxy-terminal region to the formation and regulation of the DAP complex.

Tommasi di Vignano A, Di Zenzo G, Sudol M, Cesareni G, Dente L

The carboxy-terminal region of utrophin, like the homologous proteins dystrophin, Drp2 and dystrobrevins, contains structural domains frequently involved in protein-protein interaction. These domains (WW, EF hands, ZZ and H1-H2) mediate recognition and binding to a multicomponent complex of proteins, also known as dystrophin-associated proteins (DAPs) for their association with dystrophin, the product of the gene, mutated in Duchenne muscular dystrophy. ... [more]

Throughput

• Low Throughput

Curated By

• BioGRID