BAIT
EPS8
DFNB102
epidermal growth factor receptor pathway substrate 8
GO Process (13)
GO Function (4)
GO Component (5)
Gene Ontology Biological Process
- Rac protein signal transduction [ISS]
- actin crosslink formation [ISS]
- actin filament bundle assembly [ISS]
- actin polymerization-dependent cell motility [ISS]
- barbed-end actin filament capping [ISS]
- cell proliferation [TAS]
- dendritic cell migration [ISS]
- epidermal growth factor receptor signaling pathway [TAS]
- exit from mitosis [ISS]
- positive regulation of signal transduction [TAS]
- regulation of actin filament length [ISS]
- regulation of cell shape [ISS]
- signal transduction [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
PREY
XAGE2
CT12.2, GAGED3, XAGE-2, CTD-2267G17.3
X antigen family, member 2
GO Process (0)
GO Function (0)
GO Component (0)
Homo sapiens
Two-hybrid
Bait protein expressed as a DNA binding domain (DBD) fusion and prey expressed as a transcriptional activation domain (TAD) fusion and interaction measured by reporter gene activation.
Publication
Phospho-tyrosine dependent protein-protein interaction network.
Post-translational protein modifications, such as tyrosine phosphorylation, regulate protein-protein interactions (PPIs) critical for signal processing and cellular phenotypes. We extended an established yeast two-hybrid system employing human protein kinases for the analyses of phospho-tyrosine (pY)-dependent PPIs in a direct experimental, large-scale approach. We identified 292 mostly novel pY-dependent PPIs which showed high specificity with respect to kinases and interacting proteins ... [more]
Mol. Syst. Biol. Mar. 01, 2015; 11(3);794 [Pubmed: 25814554]
Throughput
- High Throughput
Additional Notes
- phospho-tyrosine dependent, interaction occurs in the presence of a kinase
Curated By
- BioGRID