LILRB4
Gene Ontology Cellular Component
PTPN6
Gene Ontology Biological Process
- B cell receptor signaling pathway [IMP]
- abortive mitotic cell cycle [IMP]
- cell differentiation [ISO]
- cell proliferation [ISO]
- cytokine-mediated signaling pathway [TAS]
- hematopoietic progenitor cell differentiation [IMP]
- intracellular signal transduction [IDA]
- megakaryocyte development [IMP]
- natural killer cell mediated cytotoxicity [IMP]
- negative regulation of B cell receptor signaling pathway [IGI]
- negative regulation of MAP kinase activity [IMP]
- negative regulation of MAPK cascade [IMP]
- negative regulation of T cell proliferation [IMP]
- negative regulation of T cell receptor signaling pathway [IMP]
- negative regulation of humoral immune response mediated by circulating immunoglobulin [IMP]
- negative regulation of peptidyl-tyrosine phosphorylation [IMP, ISO]
- peptidyl-tyrosine dephosphorylation [IDA, ISO]
- peptidyl-tyrosine phosphorylation [ISO]
- platelet aggregation [IMP]
- platelet formation [IGI]
- positive regulation of cell adhesion mediated by integrin [IMP]
- positive regulation of cell proliferation [ISO]
- positive regulation of phosphatidylinositol 3-kinase signaling [ISO]
- protein dephosphorylation [IDA, IMP, ISO]
- regulation of B cell differentiation [IMP]
- regulation of ERK1 and ERK2 cascade [ISO]
- regulation of G1/S transition of mitotic cell cycle [ISO]
- regulation of release of sequestered calcium ion into cytosol [IGI]
- signal transduction [ISO]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Affinity Capture-Western
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.
Publication
Specificity of the SH2 domains of SHP-1 in the interaction with the immunoreceptor tyrosine-based inhibitory motif-bearing receptor gp49B.
Inhibitory receptors on hemopoietic cells critically regulate cellular function. Despite their expression on a variety of cell types, these inhibitory receptors signal through a common mechanism involving tyrosine phosphorylation of the immunoreceptor tyrosine-based inhibitory motif (ITIM), which engages Src homology 2 (SH2) domain-containing cytoplasmic tyrosine or inositol phosphatases. In this study, we have investigated the proximal signal-transduction pathway of an ... [more]
Throughput
- Low Throughput
Additional Notes
- Figure 4
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| PTPN6 LILRB4 | Protein-peptide Protein-peptide An interaction is detected between a protein and a peptide derived from an interaction partner. This includes phage display experiments. | Low | - | BioGRID | 1416187 |
Curated By
- BioGRID