BAIT
CRK
CRKII, p38
v-crk avian sarcoma virus CT10 oncogene homolog
GO Process (11)
GO Function (3)
GO Component (4)
Gene Ontology Biological Process
- Fc-gamma receptor signaling pathway involved in phagocytosis [TAS]
- activation of MAPKK activity [TAS]
- blood coagulation [TAS]
- ephrin receptor signaling pathway [IDA]
- innate immune response [TAS]
- insulin receptor signaling pathway [TAS]
- neurotrophin TRK receptor signaling pathway [TAS]
- platelet activation [TAS]
- regulation of Rho GTPase activity [IDA]
- regulation of actin cytoskeleton organization [IDA]
- regulation of transcription from RNA polymerase II promoter [TAS]
Gene Ontology Molecular Function
Homo sapiens
PREY
ISL1
ISLET1, Isl-1
ISL LIM homeobox 1
GO Process (36)
GO Function (6)
GO Component (4)
Gene Ontology Biological Process
- atrial septum morphogenesis [ISS]
- cardiac cell fate determination [IDA]
- cardiac right ventricle morphogenesis [ISS]
- cellular response to glucocorticoid stimulus [ISS]
- endocardial cushion morphogenesis [ISS]
- innervation [ISS]
- mesenchymal cell differentiation [ISS]
- negative regulation of inflammatory response [ISS]
- negative regulation of intracellular estrogen receptor signaling pathway [ISS]
- negative regulation of neuron apoptotic process [ISS]
- negative regulation of protein homodimerization activity [ISS]
- negative regulation of transcription from RNA polymerase II promoter [ISS]
- neuron fate specification [ISS]
- outflow tract morphogenesis [ISS]
- outflow tract septum morphogenesis [ISS]
- pancreas development [ISS]
- peripheral nervous system neuron axonogenesis [ISS]
- pharyngeal system development [ISS]
- positive regulation of angiogenesis [ISS]
- positive regulation of granulocyte colony-stimulating factor production [ISS]
- positive regulation of granulocyte macrophage colony-stimulating factor production [ISS]
- positive regulation of insulin secretion [IC]
- positive regulation of interferon-gamma production [ISS]
- positive regulation of interleukin-1 alpha production [ISS]
- positive regulation of interleukin-1 beta production [ISS]
- positive regulation of interleukin-12 production [ISS]
- positive regulation of interleukin-6 production [ISS]
- positive regulation of macrophage colony-stimulating factor production [ISS]
- positive regulation of transcription from RNA polymerase II promoter [ISS]
- positive regulation of tumor necrosis factor production [ISS]
- positive regulation vascular endothelial growth factor production [ISS]
- secondary heart field specification [IMP]
- sensory system development [ISS]
- spinal cord motor neuron differentiation [ISS]
- trigeminal nerve development [ISS]
- ventricular cardiac muscle tissue morphogenesis [ISS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
Two-hybrid
Bait protein expressed as a DNA binding domain (DBD) fusion and prey expressed as a transcriptional activation domain (TAD) fusion and interaction measured by reporter gene activation.
Publication
Phospho-tyrosine dependent protein-protein interaction network.
Post-translational protein modifications, such as tyrosine phosphorylation, regulate protein-protein interactions (PPIs) critical for signal processing and cellular phenotypes. We extended an established yeast two-hybrid system employing human protein kinases for the analyses of phospho-tyrosine (pY)-dependent PPIs in a direct experimental, large-scale approach. We identified 292 mostly novel pY-dependent PPIs which showed high specificity with respect to kinases and interacting proteins ... [more]
Mol. Syst. Biol. Mar. 01, 2015; 11(3);794 [Pubmed: 25814554]
Throughput
- High Throughput
Curated By
- BioGRID