BAIT
APPL2
DIP13B
adaptor protein, phosphotyrosine interaction, PH domain and leucine zipper containing 2
GO Process (2)
GO Function (1)
GO Component (5)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
PREY
CRLF3
CREME-9, CREME9, CRLM9, CYTOR4, FRWS, p48.2
cytokine receptor-like factor 3
GO Process (6)
GO Function (0)
GO Component (2)
Gene Ontology Biological Process
- G1/S transition of mitotic cell cycle [IMP]
- negative regulation of cell growth [IDA]
- positive regulation of JAK-STAT cascade [IDA]
- positive regulation of cell cycle arrest [IDA]
- positive regulation of transcription from RNA polymerase II promoter [IDA]
- positive regulation of transcription, DNA-templated [IDA]
Gene Ontology Cellular Component
Homo sapiens
Two-hybrid
Bait protein expressed as a DNA binding domain (DBD) fusion and prey expressed as a transcriptional activation domain (TAD) fusion and interaction measured by reporter gene activation.
Publication
Phospho-tyrosine dependent protein-protein interaction network.
Post-translational protein modifications, such as tyrosine phosphorylation, regulate protein-protein interactions (PPIs) critical for signal processing and cellular phenotypes. We extended an established yeast two-hybrid system employing human protein kinases for the analyses of phospho-tyrosine (pY)-dependent PPIs in a direct experimental, large-scale approach. We identified 292 mostly novel pY-dependent PPIs which showed high specificity with respect to kinases and interacting proteins ... [more]
Mol. Syst. Biol. Mar. 01, 2015; 11(3);794 [Pubmed: 25814554]
Throughput
- High Throughput
Curated By
- BioGRID